Factors affecting the physical stability (aggregation) of peptide therapeutics
KL Zapadka, FJ Becher… - Interface …, 2017 - royalsocietypublishing.org
The number of biological therapeutic agents in the clinic and development pipeline has
increased dramatically over the last decade and the number will undoubtedly continue to …
increased dramatically over the last decade and the number will undoubtedly continue to …
The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug
SM Johnson, S Connelly, C Fearns, ET Powers… - Journal of molecular …, 2012 - Elsevier
Transthyretin (TTR) is one of the many proteins that are known to misfold and aggregate (ie,
undergo amyloidogenesis) in vivo. The process of TTR amyloidogenesis causes nervous …
undergo amyloidogenesis) in vivo. The process of TTR amyloidogenesis causes nervous …
Applications of isothermal titration calorimetry in pure and applied research—survey of the literature from 2010
Isothermal titration calorimetry (ITC) is a biophysical technique for measuring the formation
and dissociation of molecular complexes and has become an invaluable tool in many …
and dissociation of molecular complexes and has become an invaluable tool in many …
Application of isothermal titration calorimetry as a tool to study natural product interactions
O Callies, AH Daranas - Natural product reports, 2016 - pubs.rsc.org
Covering: up to February 2015 Over the past twenty-five years, isothermal titration
calorimetry (ITC) has become a potent tool for the study a great variety of molecular …
calorimetry (ITC) has become a potent tool for the study a great variety of molecular …
Natural compounds as inhibitors of transthyretin amyloidosis and neuroprotective agents: Analysis of structural data for future drug design
L Ciccone, N Tonali, S Nencetti… - Journal of Enzyme …, 2020 - Taylor & Francis
Natural compounds, such as plant and fruit extracts have shown neuroprotective effect
against neurodegenerative diseases. It has been reported that several natural compounds …
against neurodegenerative diseases. It has been reported that several natural compounds …
Brain endogenous estrogen levels determine responses to estrogen replacement therapy via regulation of BACE1 and NEP in female Alzheimer's transgenic mice
R Li, P He, J Cui, M Staufenbiel, N Harada… - Molecular neurobiology, 2013 - Springer
Estrogens have been found to improve memory and reduce risk of dementia, although
conflicting results such as failure of estrogen replacement therapy for treatment of …
conflicting results such as failure of estrogen replacement therapy for treatment of …
Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity
MM Alhamadsheh, S Connelly, A Cho… - Science translational …, 2011 - science.org
A valine-to-isoleucine mutation at position 122 of the serum protein transthyretin (TTR),
found in 3 to 4% of African Americans, alters its stability, leading to amyloidogenesis and …
found in 3 to 4% of African Americans, alters its stability, leading to amyloidogenesis and …
Nearly 200 X-ray crystal structures of transthyretin: what do they tell us about this protein and the design of drugs for TTR amyloidoses?
SK Palaninathan - Current medicinal chemistry, 2012 - ingentaconnect.com
Transthyretin (TTR), a β-strand rich tetrameric protein present in human serum and
cerebrospinal fluid is involved in the transport of thyroxine and retinol binding protein: retinol …
cerebrospinal fluid is involved in the transport of thyroxine and retinol binding protein: retinol …
Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites
Transthyretin (TTR) is an amyloidogenic protein, the amyloidogenic potential of which is
enhanced by a number of specific point mutations. The ability to inhibit TTR fibrillogenesis is …
enhanced by a number of specific point mutations. The ability to inhibit TTR fibrillogenesis is …
Natural allosteric modulators and their biological targets: molecular signatures and mechanisms
Covering: 2008 to 2018 Over the last decade more than two hundred single natural products
were confirmed as natural allosteric modulators (alloNPs) of proteins. The compounds are …
were confirmed as natural allosteric modulators (alloNPs) of proteins. The compounds are …