Ageing and chronic degenerative pathologies demonstrate the shared characteristics of
high bioavailability of reactive oxygen species (ROS) and oxidative stress, chronic/persistent …

Hypoxic–ischemic encephalopathy, also referred as HIE, is a type of brain injury or damage
that is caused by a lack of oxygen to the brain during neonatal period. The incidence is …

Cerebral palsy is caused by injury or developmental disturbances to the immature brain and
leads to substantial motor, cognitive, and learning deficits. In addition to developmental …

Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating disease that primarily
causes neuronal and white matter injury and is among the leading cause of death among …

Stem cell transplantation promises new hope for the treatment of stroke although significant
questions remain about how the grafted cells elicit their effects. One hypothesis is that …

Reprogramming of adult human somatic cells to induced pluripotent stem cells (iPSCs) is a
novel approach to produce patient-specific cells for autologous transplantation. Whether …

Hypoxic-ischemic brain injury is a significant cause of morbidity and mortality in the adult as
well as in the neonate. Extensive pre-clinical studies have shown promising therapeutic …

Stem cell-based approaches to restore function after stroke through replacement of dead
neurons require the generation of specific neuronal subtypes. Loss of neurons in the …

Neural stem cells (NSCs) have garnered significant scientific and commercial interest in the
last 15 years. Given their plasticity, defined as the ability to develop into different phenotypes …

Previous work from our group has shown that intranasal MSC-treatment decreases lesion
volume and improves motor and cognitive behavior after hypoxic–ischemic (HI) brain …