Background The last decade witnessed the emergence of several therapeutic options for
patients with chronic lymphocytic leukemia (CLL) for first-line and relapsed settings. The vast …

Immunotherapy is playing an increasing role in the treatment of many cancers. The recent
advances in antibody therapy gives much optimism that both passive (antibody therapy) as …

IL12 is an essential cytokine for the generation of T helper 1 response, natural killer (NK)
cells and cytotoxic T lymphocyte (CTL) stimulation. CD154 triggers CD40 on antigen …

Abstract Murine β-defensin 2 (MBD2) is a small antimicrobial peptide of the innate immune
system. Recent study showed that MBD2 could not only recruit immature dendritic cells but …

CD80 is a molecule that plays an important role in the immune system, especially during T-
cell activation, and its ligands are mainly CD28, PD-L1, and CTLA-4. CD80 is expressed on …

Chemokines orchestrate trafficking of immune effector cells during inflammation. Here we
demonstrate that chemokines also serve to potentiate effector cell-mediated antineoplastic …

See page 846 Approaches facilitating generation of dendritic cell (DC) vaccines for clinical
trials and enhancing their viability, bio-distribution, and capacity to stimulate antigen-specific …

Acute myeloid leukemia (AML) patients treated with available therapies achieve remission in
approximately 60% of cases, but the long-term event-free survival is less than 30%. Use of …

Adult patients with acute leukemia have, in general, a poor prognosis, with long-term,
disease-free survival achieved in only approximately one-third of cases. One of the …

In an effort to enhance the potency of DNA vaccines, we have developed a new strategy to
increase antigen presentation by dendritic cells, one that results in markedly improved …