The sympathetic nervous system (SNS) is a major regulatory mediator connecting the brain
and the immune system that influences accordingly inflammatory processes within the entire …

Functional roles of SIGLEC15 in hepatocellular carcinoma (HCC) were not clear, which was
recently found to be an immune inhibitor with similar structure of inhibitory B7 family …

ABSTRACT CVA6 is one of Enteroviruses causing worldwide epidemics of HFMD with
neurological and systemic complications. A suitable animal model is necessary for studying …

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial
hyperplasia, cartilage damage, and ultimate bone destruction. The signaling lymphocytic …

BACKGROUND: Dendritic cells (DCs) regulate the immune response associated with T
lymphocytes, but their role in stroke remains unclear. In this study, we investigated the …

B cells are one of the fundamental components of the adaptive immune system and are best
known for their ability to produce antibodies. Among the various types of inborn errors of …

Immune cells that infiltrate the tumor microenvironment (TME) play crucial roles in shaping
cancer development and influencing clinical outcomes and therapeutic responses …

Objective: Synovium is home to immune and stromal cell types that orchestrate inflammation
following a joint injury; in particular, macrophages are central protagonists in this process …

Background Synovial fibrosis is a common complication of knee osteoarthritis (KOA), a
pathological process characterized by myofibroblast activation and excessive extracellular …

The importance of a local tissue immune response in healing injured tissues such as skin
and lung is well established. Little is known about whether sterile wounds elicit lymph node …