Computer simulation of genomic data has become increasingly popular for assessing and
validating biological models or for gaining an understanding of specific data sets. Several …

Motivation The accurate in silico simulation of metagenomic datasets is of great importance
for benchmarking bioinformatics tools as well as for experimental design. Users are …

Abstract Background The MinION sequencing instrument from Oxford Nanopore
Technologies (ONT) produces long read lengths from single-molecule sequencing–valuable …

Abstract Next-Generation Sequencing (NGS) technologies are expected to play a crucial
role in the surveillance of infectious diseases, with their unprecedented capabilities for the …

Background Shotgun metagenome data sets of microbial communities are highly diverse,
not only due to the natural variation of the underlying biological systems, but also due to …

In silico simulation of high-throughput sequencing data is a technique used widely in the
genomics field. However, there is currently a lack of effective tools for creating simulated …

Motivation: Third generation sequencing methods provide longer reads than second
generation methods and have distinct error characteristics. While there exist many read …

Abstract Background The Northern snakehead (Channa argus), a member of the Channidae
family of the Perciformes, is an economically important freshwater fish native to East Asia. In …

VISOR is a tool for haplotype-specific simulations of simple and complex structural variants
(SVs). The method is applicable to haploid, diploid or higher ploidy simulations for bulk or …

Although transcriptome alteration is an essential driver of carcinogenesis, the effects of
chromosomal structural alterations on the cancer transcriptome are not yet fully understood …