Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration
DA Ferrington, D Sinha, K Kaarniranta - Progress in retinal and eye …, 2016 - Elsevier
Maintenance of protein homeostasis, also referred to as “Proteostasis”, integrates multiple
pathways that regulate protein synthesis, folding, translocation, and degradation. Failure in …
pathways that regulate protein synthesis, folding, translocation, and degradation. Failure in …
The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges
GR Tundo, D Sbardella, AM Santoro, A Coletta… - Pharmacology & …, 2020 - Elsevier
Abstract Ubiquitin Proteasome System (UPS) is an adaptable and finely tuned system that
sustains proteostasis network under a large variety of physiopathological conditions. Its …
sustains proteostasis network under a large variety of physiopathological conditions. Its …
Targeting immunoproteasome in neurodegeneration: A glance to the future
GR Tundo, P Cascio, D Milardi, AM Santoro… - Pharmacology & …, 2023 - Elsevier
The immunoproteasome is a specialized form of proteasome equipped with modified
catalytic subunits that was initially discovered to play a pivotal role in MHC class I antigen …
catalytic subunits that was initially discovered to play a pivotal role in MHC class I antigen …
At the cutting edge against cancer: a perspective on immunoproteasome and immune checkpoints modulation as a potential therapeutic intervention
GR Tundo, D Sbardella, F Oddone, AA Kudriaeva… - Cancers, 2021 - mdpi.com
Simple Summary Immunoproteasome plays a key role in the generation of antigenic
peptides. Immune checkpoints therapy is a front-line treatment of advanced/metastatic …
peptides. Immune checkpoints therapy is a front-line treatment of advanced/metastatic …
Ablation of immunoproteasome β5i subunit suppresses hypertensive retinopathy by blocking ATRAP degradation in mice
S Wang, J Li, T Wang, J Bai, YL Zhang, QY Lin, J Li… - Molecular Therapy, 2020 - cell.com
Inflammation is associated with retinal diseases. Our recent data demonstrate that
immunoproteasome catalytic subunit β2i contributes to angiotensin II (Ang II)-induced …
immunoproteasome catalytic subunit β2i contributes to angiotensin II (Ang II)-induced …
[HTML][HTML] The immunoproteasome subunit LMP10 mediates angiotensin II-induced retinopathy in mice
S Wang, J Li, J Bai, JM Li, YL Che, QY Lin, YL Zhang… - Redox biology, 2018 - Elsevier
Inflammation has been implicated in a variety of retinal diseases. The immunoproteasome
plays a critical role in controlling inflammatory responses, but whether activation of …
plays a critical role in controlling inflammatory responses, but whether activation of …
Investigating AKT activation and autophagy in immunoproteasome-deficient retinal cells
MR Karim, CR Fisher, RJ Kapphahn, JR Polanco… - PLoS …, 2020 - journals.plos.org
Two major proteolytic systems, the proteasome and the autophagy pathway, are key
components of the proteostasis network. The immunoproteasome, a proteasome subtype …
components of the proteostasis network. The immunoproteasome, a proteasome subtype …
A re-appraisal of pathogenic mechanisms bridging wet and dry age-related macular degeneration leads to reconsider a role for phytochemicals
R Pinelli, F Biagioni, F Limanaqi, M Bertelli… - International Journal of …, 2020 - mdpi.com
Which pathogenic mechanisms underlie age-related macular degeneration (AMD)? Are they
different for dry and wet variants, or do they stem from common metabolic alterations …
different for dry and wet variants, or do they stem from common metabolic alterations …
[HTML][HTML] PDGF-D-induced immunoproteasome activation and cell-cell interactions
J Zhang, W Li, Z Xiong, J Zhu, X Ren, S Wang… - Computational and …, 2023 - Elsevier
Platelet-derived growth factor-D (PDGF-D) is abundantly expressed in ocular diseases. Yet,
it remains unknown whether and how PDGF-D affects ocular cells or cell-cell interactions in …
it remains unknown whether and how PDGF-D affects ocular cells or cell-cell interactions in …
CD200Fc attenuates retinal glial responses and RGCs apoptosis after optic nerve crush by modulating CD200/CD200R1 interaction
R Huang, Q Lan, L Chen, H Zhong, L Cui… - Journal of Molecular …, 2018 - Springer
To explore the hypothesis that CD200Fc, a CD200R1 agonist with anti-inflammatory
properties, will inhibit retinal glial cells hyperactivation and retinal ganglion cells (RGCs) …
properties, will inhibit retinal glial cells hyperactivation and retinal ganglion cells (RGCs) …