Listen to an interview with David Scadden on the stem cells podcast Stem-cell populations
are established in 'niches'—specific anatomic locations that regulate how they participate in …

Adult tissue-specific stem cells have the capacity to self-renew and generate functional
differentiated cells that replenish lost cells throughout an organism's lifetime. Studies on …

The concept that stem cells are controlled by particular microenvironments known as' niches'
has been widely invoked. But niches have remained largely a theoretical construct because …

Cell signaling plays a key role in the development of all multicellular organisms. Numerous
studies have established the importance of Hedgehog signaling in a wide variety of …

The piwi family genes, which are defined by conserved PAZ and Piwi domains, play
important roles in stem cell self-renewal, RNA silencing, and translational regulation in …

RNA interference (RNAi) is an evolutionarily conserved process through which double-
stranded RNA (dsRNA) induces the silencing of cognate genes (for review, see Bernstein et …

To directly test the requirement for hedgehog signaling in the telencephalon from early
neurogenesis, we examined conditional null alleles of both the Sonic hedgehog and …

A number of genes have been identified as members of the Argonaute family in various
nonhuman organisms and these genes are considered to play important roles in the …

Mammalian cells harbor numerous small non-protein-coding RNAs, including small
nucleolar RNAs (snoRNAs), microRNAs (miRNAs), short interfering RNAs (siRNAs) and …

Stem cells execute self-renewing and asymmetric cell divisions in close association with
stromal cells that form a niche [1]. The mechanisms that link stromal cell signaling to self …