Genome integrity is constantly challenged by endogenous and exogenous insults that cause
DNA damage. To cope with these threats, cells have a surveillance mechanism, known as …

Defects in DNA repair pathways are emerging hallmarks of cancer. Accurate DNA repairs
and replications are essential for genomic stability. Cancer cells require residual DNA repair …

Simple Summary We studied the relationship between enhancement of DNA repair and
cancer aggressiveness, tumor immune microenvironment, and patient survival in 749 …

Cancer cells undergo transcriptional reprogramming to drive tumor progression and
metastasis. Using cancer cell lines and patient-derived tumor organoids, we demonstrate …

Resistance to radiotherapy is a major barrier during cancer treatment. Here using genome-
scale CRISPR/Cas9 screening, we identify CD274 gene, which encodes PD-L1, to confer …

Genomic integrity is continuously threatened by thousands of endogenous and exogenous
damaging factors. To preserve genome stability, cells developed comprehensive DNA …

DNA double-strand breaks (DSBs) are highly toxic lesions that threaten genome integrity
and cell survival. To avoid harmful repercussions of DSBs, a wide variety of DNA repair …

RNA polymerase (Pol) II is highly regulated to ensure appropriate gene expression. Early
transcription elongation is associated with transient pausing of RNA Pol II in the promoter …

Background: Colorectal cancer (CRC) ranks among the leading causes of cancerrelated
deaths. Objective: This study aimed to illuminate the relationship between DPP7 (also …

Background: The RAD51 recombinase is involved in homologous recombination and DNA
repair. However, the association of RAD51 with the prognosis of adenocarcinoma at the …