Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are serious
health problems worldwide. These two diseases have similar pathological spectra, ranging …

Alcohol use disorders (AUDs) is one of the leading causes of disease and disability in
almost all European countries. Among the alcohol-related diseases, alcoholic liver disease …

Abstract Background and Aims Pharmacologically controlled drinking in the treatment of
alcohol dependence or alcohol use disorders (AUDs) is an emerging concept. Our objective …

Drug use typically occurs within a social context, and social factors play an important role in
the initiation, maintenance and recovery from addictions. There is now accumulating …

The British Association for Psychopharmacology guidelines for the treatment of substance
abuse, harmful use, addiction and comorbidity with psychiatric disorders primarily focus on …

Aims Alcohol dependence is a major public health issue with a need for new
pharmacological treatments. The ALPADIR study assessed the efficacy and safety of …

Alcohol-use-disorders (AUDs) afflict 1–3% of elderly subjects. The CAGE, SMAST-G, and
AUDIT are the most common and validated questionnaires used to identify AUDs in the …

Previous randomised placebo-controlled trials with low-to-medium doses of baclofen (30–60
mg) showed inconsistent results, but case studies suggested a dose-response effect and …

Studies of the neurobiological predisposition to consume alcohol (ethanol) and to transition
to uncontrolled drinking behavior (alcoholism), as well as studies of the effects of alcohol on …

Previous randomized, placebo-controlled trials (RCTs) assessing the efficacy of the
selective γ-aminobutyric acid (GABA)-B receptor agonist baclofen in the treatment of alcohol …