Heterogeneous synthetic vesicles toward artificial cells: engineering structure and composition of membranes for multimodal functionalities

J Shin, BD Cole, T Shan, Y Jang - Biomacromolecules, 2022 - ACS Publications
The desire to develop artificial cells to imitate living cells in synthetic vesicle platforms has
continuously increased over the past few decades. In particular, heterogeneous synthetic …

[HTML][HTML] Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens

RA Quinlan, JI Clark - Journal of Biological Chemistry, 2022 - ASBMB
In the human eye, a transparent cornea and lens combine to form the" refracton" to focus
images on the retina. This requires the refracton to have a high refractive index" n," mediated …

Environmentally relevant concentrations of F–53B induce eye development disorders-mediated locomotor behavior in zebrafish larvae

L Wu, M Zeeshan, Y Dang, LY Liang, YC Gong, QQ Li… - Chemosphere, 2022 - Elsevier
The perfluorooctane sulfonate alternative, F–53B, induces multiple physiological defects but
whether it can disrupt eye development is unknown. We exposed zebrafish to F–53B at four …

[HTML][HTML] Signaling mechanisms and pharmacological modulators governing diverse aquaporin functions in human health and disease

K Wagner, L Unger, MM Salman, P Kitchen… - International Journal of …, 2022 - mdpi.com
The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the
bidirectional transport of water across biological membranes in response to osmotic …

[HTML][HTML] Age-related changes in eye lens biomechanics, morphology, refractive index and transparency

C Cheng, J Parreno, RB Nowak, SK Biswas… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Life-long eye lens function requires an appropriate gradient refractive index, biomechanical
integrity and transparency. We conducted an extensive study of wild-type mouse lenses 1 …

Lens aquaporins function as peroxiporins to facilitate membrane transport of hydrogen peroxide

K Varadaraj, SS Kumari - Biochemical and biophysical research …, 2020 - Elsevier
High levels of reactive oxygen species such as hydrogen peroxide (H 2 O 2) cause oxidative
stress in the lens and lead to cataractogenesis. The present investigation was undertaken to …

Fibronectin has multifunctional roles in posterior capsular opacification (PCO)

MH Shihan, M Kanwar, Y Wang, EE Jackson… - Matrix Biology, 2020 - Elsevier
Fibrotic posterior capsular opacification (PCO), one of the major complications of cataract
surgery, occurs when lens epithelial cells (LCs) left behind post cataract surgery (PCS) …

[HTML][HTML] Physiological mechanisms regulating lens transport

AA Giannone, L Li, C Sellitto, TW White - Frontiers in Physiology, 2021 - frontiersin.org
The transparency and refractive properties of the lens are maintained by the cellular
physiology provided by an internal microcirculation system that utilizes spatial differences in …

[HTML][HTML] Lysine fatty acylation: regulatory enzymes, research tools, and biological function

G Komaniecki, H Lin - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Post-translational acylation of lysine side chains is a common mechanism of protein
regulation. Modification by long-chain fatty acyl groups is an understudied form of lysine …

Protective roles of peroxiporins AQP0 and AQP11 in human astrocyte and neuronal cell lines in response to oxidative and inflammatory stressors

Z Amro, LE Collins-Praino, AJ Yool - Bioscience Reports, 2024 - portlandpress.com
In addition to aquaporin (AQP) classes AQP1, AQP4 and AQP9 known to be expressed in
mammalian brain, our recent transcriptomic analyses identified AQP0 and AQP11 in human …