Cytosolic Ca 2+ concentration levels fluctuate in an ordered manner along the cell cycle, in
line with the fact that Ca 2+ is involved in the regulation of cell proliferation. Cell proliferation …

Colorectal cancer is a multifaceted disease which is therapeutically challenging. Based on
insights gleaned from almost a quarter century of research, it is obvious that deregulation of …

The human selenoprotein family contains 25 members that share the common feature of
containing the amino acid, selenocysteine (Sec). Seven selenoproteins are localized to the …

Cancer, the second cause of death worldwide, is characterized by several common criteria,
known as the “cancer hallmarks” such as unrestrained cell proliferation, cell death …

Transient receptor potential channels convey signaling information from a number of stimuli
to a wide variety of cellular functions, mainly by inducing changes in cytosolic Ca2+ …

In their seminal papers Hanahan and Weinberg described oncogenic processes a normal
cell undergoes to be transformed into a cancer cell. The functions of ion channels in the …

Caffeine is a purine alkaloid and is widely consumed in coffee, soda, tea, chocolate and
energy drinks. To date, a growing number of studies have indicated that caffeine is …

Transient receptor potential canonical (TRPC) channels are the most prominent
nonselective cation channels involved in various diseases. However, the function, clinical …

Background: Colorectal cancer (CRC) is a highly devastating cancer. Ca2+-dependent
channels are now considered key regulators of tumor progression. In this study, we aimed to …

Epithelial Ovarian cancer (EOC) is the deadliest gynecologic malignancy and represents the
fifth leading cause of all cancer-related deaths in women. The majority of patients are …