Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …

There has been recent renewed interest in studying human early embryonic development.
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …

Current single-cell RNA-sequencing approaches have limitations that stem from the
microfluidic devices or fluid handling steps required for sample processing. We develop a …

The cellular landscape of the human intestinal tract is dynamic throughout life, developing in
utero and changing in response to functional requirements and environmental exposures …

Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …

Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

In the past decade, the term organoid has moved from obscurity to common use to describe
a 3D in vitro cellular model of a tissue that recapitulates structural and functional elements of …

Human skin uses millions of hairs and glands distributed across the body surface to function
as an external barrier, thermoregulator and stimuli sensor. The large-scale generation of …

International efforts are underway to provide a comprehensive survey of cells across the
human life span (,). These efforts assign cell “types” on the basis of a set of information-rich …

Molecular interactions are key drivers of biological function. Providing interaction resources
to the research community is important since they allow functional interpretation and network …