Fever is a cardinal response to infection that has been conserved in warm-blooded and cold-
blooded vertebrates for more than 600 million years of evolution. The fever response is …

Within the tumor microenvironment, IL-6 signaling is generally considered a malevolent
player, assuming a dark visage that promotes tumor progression. Chronic IL-6 signaling is …

Hyperthermia (HT) is a potent sensitiser for radiotherapy (RT) and chemotherapy (CT) and
has been proven to modulate directly or indirectly cells of the innate and adaptive immune …

Simple Summary The current immune, metabolic, and neural pathways and the structures
involved in developing the febrile response and, in return, to thermal homeostasis are …

Given the manifold ways that depression impairs Darwinian fitness, the persistence in the
human genome of risk alleles for the disorder remains a much debated mystery …

The predominant role of IL-6 in cancer is its key promotion of tumour growth. IL-6 binds IL-6
receptor (IL-6R) and the membrane-bound glycoprotein gp130. The complex I-6/IL …

A major goal of cancer immunotherapy is to stimulate the generation of long-lasting, tumor
antigen–specific immune responses that recognize and destroy tumor cells. This article …

Photodynamic therapy (PDT) of tumour results in the rapid induction of an inflammatory
response that is considered important for the activation of antitumour immunity, but may be …

Immune checkpoint inhibitors (ICIs) have ushered in a new era of cancer therapy; however,
ICIs are only effective in selective patients. The efficacy of ICIs is closely related to the tumor …

Immune cells are key regulators of neoplastic progression, which is often mediated through
their release of cytokines. Inflammatory cytokines such as IL-6 exert tumor-promoting …