The interface between relay and converter domain of muscle myosin is critical for optimal
myosin performance. Using Drosophila melanogaster indirect flight muscle S1, we …

Detecting associations between genomic changes and phenotypic differences is
fundamental to understanding how phenotypes evolved. By systematically screening for …

Locust (Locusta migratoria) has a single striated muscle myosin heavy chain (Mhc) gene,
which contains 5 clusters of alternative exclusive exons and 1 differently included …

Structural interactions between the myosin converter and relay domains have been
proposed to be critical for the myosin power stroke and muscle power generation. We tested …

Our molecular modeling studies suggest a charge-dependent interaction between residues
Glu-497 in the relay domain and Arg-712 in the converter domain of human β-cardiac …

Intramolecular communication within myosin is essential for its function as motor, but the
specific amino acid residue interactions required are unexplored within muscle cells. Using …

Myosin isoforms help define muscle-specific contractile and structural properties. Alternative
splicing of myosin heavy chain gene transcripts in Drosophila melanogaster yields muscle …

We are investigating the influence of the converter and relay domains on elementary rate
constants of the actomyosin cross-bridge cycle. The converter and relay domains vary …

Biophysical and structural studies on muscle myosin rely upon milligram quantities of
extremely pure material. However, many biologically interesting myosin isoforms are …

Two Drosophila myosin II point mutations (D45 and Mhc 5) generate Drosophila cardiac
phenotypes that are similar to dilated or restrictive human cardiomyopathies. Our homology …