Human-induced pluripotent stem cells (hiPSCs) and CRISPR/Cas9 gene editing system
represent two instruments of basic and translational research, which both allow to acquire …

Colorectal cancer (CRC) patients with liver metastases usually obtain less benefit from
immunotherapy, and the underlying mechanisms remain understudied. Here, we identify …

The liver is one of the largest organs in the body and is responsible for a diverse repertoire
of metabolic processes. Such processes include the secretion of serum proteins …

Personalized medicine aims to provide tailored medical treatment that considers the clinical,
genetic, and environmental characteristics of patients. iPSCs have attracted considerable …

Liver plays a major role in drug metabolism and is one of the main sites of drug adverse
effects. Microphysiological systems (MPS), also known as organs‐on‐a‐chip, are a class of …

Human stem cell-derived hepatocyte-like cells (HLCs) offer an attractive platform to study
liver biology. Despite their numerous advantages, HLCs lack critical in vivo characteristics …

Pluripotent stems cells (PSCs) can be expanded indefinitely and differentiated into almost
any organ-specific cell type. This has enabled the generation of disease relevant tissues …

Hepatitis B virus (HBV) infection affects~ 350 million people and poses a major public health
problem worldwide. HBV is a major cause of cirrhosis and hepatocellular carcinoma. Fewer …

Induced pluripotent stem cells (iPSCs) are an essential tool for studying cellular
differentiation and cell types that are otherwise difficult to access. We investigated the use of …

Human induced pluripotent stem cells (hiPSCs) were first generated in 2007, but the full
translational potential of this valuable tool has yet to be realized. The potential applications …