INTRODUCTION The faithful replication and segregation of chromosomes as part of the cell
division cycle requires that topological changes be imposed upon cellular DNA …

The compaction of linear DNA into micrometer-sized nuclear boundaries involves the
establishment of specific three-dimensional (3D) DNA structures complexed with histone …

The two strands of a closed circular DNA molecule possess as a topological invariant their
linking number. This property, combined with an appreciable twist elastic constant, causes …

Abstract 13S condensin is a five-subunit protein complex that plays a central role in mitotic
chromosome condensation in Xenopus egg extracts. Two core subunits of this complex …

Because RNA polymerase is a powerful motor, transmission of transcription-generated
forces might directly alter DNA structure, chromatin or gene activity in mammalian cells. Here …

We have used computer-assisted methods to search large amounts of the human, yeast and
Escherichla coll genomes for inverted repeat (IR) and mirror repeat (MR) DNA sequence …

Transcription-coupled supercoiling of DNA is a key factor in chromosome compaction and
the regulation of genetic processes in all domains of life. It has become common knowledge …

Through dynamic changes in structure resulting from DNA–protein interactions and
constraints given by the structural features of the double helix, chromatin accommodates …

We have investigated the molecular mechanism by which the proto-oncogene protein DEK,
an abundant chromatin-associated protein, changes the topology of DNA in chromatin in …

Type III restriction/modification systems recognize short non‐palindromic sequences, only
one strand of which can be methylated. Replication of type III‐modified DNA produces …