Abstract Disruption of Akt and Erk-mediated signal transduction significantly contributes in
the pathogenesis of various neurodegenerative diseases (NDs), such as Parkinson's …

The signaling pathway of the microtubule-associated protein kinase or extracellular
regulated kinase (MAPK/ERK) is a common mechanism of extracellular information …

Calcium modulates many neural processes, including synaptic plasticity and apoptosis.
Dysregulation of intracellular calcium signalling has been implicated in the pathogenesis of …

The DISC locus is located at the breakpoint of a balanced t (1; 11) chromosomal
translocation in a large and unique Scottish family. This translocation segregates in a highly …

Because disease-associated microglia (DAM) and disease-associated astrocytes (DAA) are
involved in the pathophysiology of Alzheimer's disease (AD), we systematically identified …

Abstract Aims Reactive astrocytes in Alzheimer's disease (AD) have traditionally been
demonstrated by increased glial fibrillary acidic protein (GFAP) immunoreactivity; however …

Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide.
Several findings suggest that correcting the dysregulated signaling pathways may offer a …

The extracellular‐signal regulated kinases 1/2 (ERK or ERKs) are involved in the regulation
of important neuronal functions, including neuronal plasticity in normal and pathological …

The amyloid precursor protein (APP) is a transmembrane protein that plays major roles in
the regulation of several important cellular functions, especially in the nervous system …

With the long-standing amyloid cascade hypothesis (ACH) largely discredited, there is an
acute need for a new all-encompassing interpretation of Alzheimer's disease (AD). Whereas …