During host immune response, an initial and sufficient activation is required to avoid
infection and cancer, yet an excessive activation bears the risk of autoimmune reactivity and …

Simple Summary CD3 complex provides the first signal sensed by the TCR of the
lymphocyte to trigger its activation. Thus, it becomes a very attractive receptor to determine …

The T cell receptor (TCR) is thought to be a mechanosensor, meaning that it transmits
mechanical force to its antigen and leverages the force to amplify the specificity and …

Neuroinflammation is a common feature of many neurodegenerative diseases. It fosters a
dysfunctional neuron–microglia–astrocyte crosstalk that, in turn, maintains microglial cells in …

The T‐cell receptor (TCR)–CD3 complex, expressed on T cells, determines the outcome of a
T‐cell response. It consists of the TCR‐αβ heterodimer and the non‐covalently associated …

The T cell receptor (TCR) is one of the most complicated receptors in mammalian cells, and
its triggering mechanism remains mysterious. As an octamer complex, TCR comprises an …

Pericytes are mural cells that surround capillaries and control angiogenesis and capillary
barrier function. During sprouting angiogenesis, endothelial cell-derived platelet-derived …

The αβ T‐cell receptor (TCR) is a multiprotein complex controlling the activation of T cells.
Although the structure of the complete TCR is not known, cumulative evidence supports that …

Mechanical forces are crucial for biological processes such as T cell antigen recognition. A
suite of molecular tension probes to measure pulling forces have been reported over the …

Autoimmune diseases are caused by antigenically complex immune responses of the
adaptive and innate immune system against specific cells, tissues or organs. Antigen …