Triple negative breast cancer (TNBC) has a negative expression of estrogen receptors (ER),
progesterone receptors (PR), and human epidermal growth factor receptors (HER2). The …

Tamoxifen (TAM), as a hydrophobic drug, is a selective estrogen modulator (SERM) applied
to hormone therapy for breast cancer (BC). Although it is effective and affordable in BC …

The blood–brain barrier (BBB) is a natural obstacle for drug delivery into the human brain,
hindering treatment of central nervous system (CNS) disorders such as acute ischemic …

Thermo-sensitive composite microspheres (TPCP) were developed to achieve the on-
demand release of drugs. The TPCP microspheres were synthesized using Oil-in-Water …

Glioblastoma (GBM) is a highly aggressive cancer that currently lacks effective treatments.
Pyroptosis has emerged as a promising therapeutic approach for cancer, but there is still a …

The clinical utility of gemcitabine, an antimetabolite antineoplastic agent applied in various
chemotherapy treatments, is limited due to the required intravenous injection. Although …

Based on their excellent biocompatibility and adjustable biodegradability, the two natural
polyesters polylactic acid (PLA) and polyhydroxyalkanoates (PHAs) have been widely used …

Cancer is a heterogeneous disease with multifaceted drug resistance mechanisms (eg,
tumour microenvironment [TME], tumour heterogeneity, and immune evasion). Natural …

In the context of inefficient antibiotics, antibacterial alternatives are urgently needed to stop
the increasing resistance rates in pathogens. This study reports the fabrication and …

It is always a challenge to encapsulate water-soluble peptides in polymer nanoparticle (NP)
systems. We establish and validate our newly developed non-aqueous nanoprecipitation …