The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …

Abstract Treatment resistant schizophrenia (TRS) refers to the significant proportion of
schizophrenia patients who continue to have symptoms and poor outcomes despite …

In people suffering from schizophrenia, major areas of everyday life are impaired, including
independent living, productive activities and social relationships. Enhanced understanding …

Although dementia praecox or schizophrenia has been considered a unique disease entity
for the past century, its definitions and boundaries have continued to vary over this period. At …

Employment is the highest priority for many people with severe mental illness and it is a
central aspect of recovery. Over the past two decades, the Individual Placement and Support …

Background People who suffer from severe mental disorder experience high rates of
unemployment. Supported employment is an approach to vocational rehabilitation that …

The identification of schizophrenia's negative symptoms dates back to the earliest
descriptions of Kraepelin and Bleuler, who each highlighted the central role of avolition in …

Disability is pervasive in schizophrenia and is refractory to current medication treatments.
Inability to function in everyday settings is responsible for the huge indirect costs of …

Patients with schizophrenia often fail to respond to an initial course of therapy. This study
systematically reviewed the societal and economic burden of treatment-resistant …

Objective: Schizophrenia and bipolar disorder are associated with multidimensional
disability. This study examined differential predictors of functional deficits in the two …