Hypoxia-inducible factor signaling in pulmonary hypertension
SS Pullamsetti, A Mamazhakypov… - The Journal of …, 2020 - Am Soc Clin Investig
Pulmonary hypertension (PH) is characterized by pulmonary artery remodeling that can
subsequently culminate in right heart failure and premature death. Emerging evidence …
subsequently culminate in right heart failure and premature death. Emerging evidence …
The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes
SC Pugliese, JM Poth, MA Fini… - … of Physiology-Lung …, 2015 - journals.physiology.org
Hypoxic pulmonary hypertension (PH) comprises a heterogeneous group of diseases
sharing the common feature of chronic hypoxia-induced pulmonary vascular remodeling …
sharing the common feature of chronic hypoxia-induced pulmonary vascular remodeling …
Airway smooth muscle in airway reactivity and remodeling: what have we learned?
YS Prakash - American Journal of Physiology-Lung Cellular …, 2013 - journals.physiology.org
It is now established that airway smooth muscle (ASM) has roles in determining airway
structure and function, well beyond that as the major contractile element. Indeed, changes in …
structure and function, well beyond that as the major contractile element. Indeed, changes in …
Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets
Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …
Multiple functions of hypoxia-regulated miR-210 in cancer
Q Qin, W Furong, L Baosheng - Journal of Experimental & Clinical Cancer …, 2014 - Springer
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-
transcriptionally. miRNAs can be induced by a variety of stresses such as hypoxia, and are …
transcriptionally. miRNAs can be induced by a variety of stresses such as hypoxia, and are …
Role of microRNAs in lung development and pulmonary diseases
MicroRNAs (miRNAs) are a class of small noncoding RNA which exert post-transcriptional
gene regulation activity by targeting messenger RNAs. miRNAs have been found to be …
gene regulation activity by targeting messenger RNAs. miRNAs have been found to be …
MicroRNAs in pulmonary arterial hypertension
G Zhou, T Chen, JU Raj - American journal of respiratory cell and …, 2015 - atsjournals.org
Pulmonary arterial hypertension (PAH) is a devastating disease without effective treatment.
Despite decades of research and the development of novel treatments, PAH remains a fatal …
Despite decades of research and the development of novel treatments, PAH remains a fatal …
MicroRNAs in pulmonary arterial hypertension: pathogenesis, diagnosis and treatment
J Bienertova-Vasku, J Novak, A Vasku - Journal of the American Society of …, 2015 - Elsevier
Pulmonary arterial hypertension (PAH) is a severe and increasingly prevalent disease,
manifested by the maladaptation of pulmonary vasculature, which consequently leads to …
manifested by the maladaptation of pulmonary vasculature, which consequently leads to …
miR-210: fine-tuning the hypoxic response
M Ivan, X Huang - … and Cellular Stress: Signaling, Metabolism, Imaging …, 2014 - Springer
Hypoxia is a central component of the tumor microenvironment and represents a major
source of therapeutic failure in cancer therapy. Recent work has provided a wealth of …
source of therapeutic failure in cancer therapy. Recent work has provided a wealth of …
Genetic and hypoxic alterations of the micro RNA‐210‐ISCU 1/2 axis promote iron–sulfur deficiency and pulmonary hypertension
Abstract Iron–sulfur (Fe‐S) clusters are essential for mitochondrial metabolism, but their
regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that …
regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that …