Traditional views of cellular metabolism imply that it is passively adapted to meet the
demands of the cell. It is becoming increasingly clear, however, that metabolites do more …

The mitochondrial carrier system (MCS) transports small molecules between mitochondria
and the cytoplasm. It is integral to the core mitochondrial function to regulate cellular …

Metabolic networks are interconnected and influence diverse cellular processes. The protein-
metabolite interactions that mediate these networks are frequently low affinity and …

Recent data suggest that the majority of proteins bind specific metabolites, and that such
interactions are relevant to metabolic and gene regulation,,. However, there are no methods …

Metabolic flux is in part regulated by endogenous small molecules that modulate the
catalytic activity of an enzyme, eg, allosteric inhibition. In contrast to transcriptional …

Identification of regulatory enzymes is fundamental for engineering metabolic pathways
such as the isoprenoid one. All too often, investigation of gene expression remains the major …

Metabolite binding to proteins regulates nearly all cellular processes, but our knowledge of
these interactions originates primarily from empirical in vitro studies. Here, we report the first …

By combining advanced omics technology and computational modeling, systems biologists
have identified and inferred thousands of regulatory events and system-wide interactions of …

Crystal structures of peroxisome proliferator-activated receptor gamma (PPARγ) have
revealed overlapping binding modes for synthetic and natural/endogenous ligands …

Protein–protein interactions often regulate the activity of protein kinases by allosterically
modulating the conformation of the ATP-binding site. Bidirectional allostery implies that …