Current status of pH-sensitive liposomes in drug delivery

DC Drummond, M Zignani, JC Leroux - Progress in lipid research, 2000 - Elsevier
Liposomes are being increasingly utilized to deliver drugs, enzymes, antisense
oligonucleotides, and genes to various therapeutic targets. Liposome-mediated delivery of …

Poly (amidoamine) s: Past, present, and perspectives

P Ferruti - Journal of Polymer Science Part A: Polymer …, 2013 - Wiley Online Library
Poly (amidoamine) s (PAAs) are a family of synthetic polymers obtained by stepwise
polyaddition of prim‐or sec‐amines to bisacrylamides. Nearly all conceivable …

Poly (amido‐amine) s: Biomedical Applications

P Ferruti, MA Marchisio… - Macromolecular Rapid …, 2002 - Wiley Online Library
Abstract Poly (amido‐amine) s (PAAs) are synthetic tert‐amino polymers obtained by
stepwise polyaddition of primary or secondary aliphatic amines to bis (acrylamide) s. Linear …

PEG grafted polylysine with fusogenic peptide for gene delivery: high transfection efficiency with low cytotoxicity

H Lee, JH Jeong, TG Park - Journal of Controlled Release, 2002 - Elsevier
For efficient gene delivery into cells, a new formulation method based on using polyethylene
glycol (PEG) grafted poly (l-lysine)(PLL) and a fusogenic peptide is presented in this study …

Poly (amidoamine) s as potential nonviral vectors: ability to form interpolyelectrolyte complexes and to mediate transfection in vitro

SCW Richardson, NG Pattrick, YK Stella Man… - …, 2001 - ACS Publications
Poly (amidoamine) s (PAAs) are water-soluble polymers that display pH-dependent
membrane activity. PAAs have the potential to act as a synthetic alternative to fusogenic …

In vitro cytotoxicity of poly (amidoamine) s: relevance to DNA delivery

IRC Hill, MC Garnett, F Bignotti, SS Davis - Biochimica et Biophysica Acta …, 1999 - Elsevier
We have examined the cytotoxicity of a number of poly (amidoamine) polymers which have
been proposed for use as DNA delivery systems and compared them to the charged …

Synthesis and degradation of pH-sensitive linear poly (amidoamine) s

R Jain, SM Standley, JMJ Frechet - Macromolecules, 2007 - ACS Publications
The design and synthesis of a family of cationic, pH-sensitive poly (amidoamine) s are
reported. Acetal or ketal linkages were incorporated into the backbone of the polymers to …

Linear polyamidoamines as novel biocompatible phosphorus-free surface-confined intumescent flame retardants for cotton fabrics

A Manfredi, F Carosio, P Ferruti, E Ranucci… - Polymer Degradation and …, 2018 - Elsevier
Eight linear polyamidoamines (PAAs) prepared by polyaddition of amines to bisacrylamides
are investigated as intumescent surface-confined flame retardants for cotton textiles. The …

Polyamidoamine and polyglycerol; their linear, dendritic and linear–dendritic architectures as anticancer drug delivery systems

E Mohammadifar, AN Kharat, M Adeli - Journal of Materials Chemistry …, 2015 - pubs.rsc.org
Despite extensive investigations in the field of cancer diagnosis and therapy in recent
decades, cancer is still the major cause of morbidity and mortality all over the world …

Poly(ethylenimine-co-l-lactamide-co-succinamide):  A Biodegradable Polyethylenimine Derivative with an Advantageous pH-Dependent Hydrolytic Degradation for …

H Petersen, T Merdan, K Kunath, D Fischer… - Bioconjugate …, 2002 - ACS Publications
A biodegradable gene transfer vector has been synthesized by linking several low
molecular weight (MW) polyethylenimine (PEI, 1200 Da) blocks using an oligo (l-lactic acid …