Adult hippocampal neurogenesis, fear generalization, and stress

A Besnard, A Sahay - Neuropsychopharmacology, 2016 - nature.com
The generalization of fear is an adaptive, behavioral, and physiological response to the
likelihood of threat in the environment. In contrast, the overgeneralization of fear, a cardinal …

Context, emotion, and the strategic pursuit of goals: interactions among multiple brain systems controlling motivated behavior

AJ Gruber, RJ McDonald - Frontiers in behavioral neuroscience, 2012 - frontiersin.org
Motivated behavior exhibits properties that change with experience and partially dissociate
among a number of brain structures. Here, we review evidence from rodent experiments …

Optogenetic stimulation of a hippocampal engram activates fear memory recall

X Liu, S Ramirez, PT Pang, CB Puryear… - Nature, 2012 - nature.com
A specific memory is thought to be encoded by a sparse population of neurons,. These
neurons can be tagged during learning for subsequent identification and manipulation …

Modulating neuronal competition dynamics in the dentate gyrus to rejuvenate aging memory circuits

KM McAvoy, KN Scobie, S Berger, C Russo, N Guo… - Neuron, 2016 - cell.com
The neural circuit mechanisms underlying the integration and functions of adult-born dentate
granule cell (DGCs) are poorly understood. Adult-born DGCs are thought to compete with …

Disambiguating the similar: the dentate gyrus and pattern separation

B Schmidt, DF Marrone, EJ Markus - Behavioural brain research, 2012 - Elsevier
The human hippocampus supports the formation of episodic memory without confusing new
memories with old ones. To accomplish this, the brain must disambiguate memories (ie …

The transcription factor Zif268/Egr1, brain plasticity, and memory

A Veyrac, A Besnard, J Caboche, S Davis… - Progress in molecular …, 2014 - Elsevier
The capacity to remember our past experiences and organize our future draws on a number
of cognitive processes that allow our brain to form and store neural representations that can …

Adult neurogenesis in the mammalian hippocampus: why the dentate gyrus?

LJ Drew, S Fusi, R Hen - Learning & memory, 2013 - learnmem.cshlp.org
In the adult mammalian brain, newly generated neurons are continuously incorporated into
two networks: interneurons born in the subventricular zone migrate to the olfactory bulb …

Acute neuroinflammation impairs context discrimination memory and disrupts pattern separation processes in hippocampus

J Czerniawski, JF Guzowski - Journal of Neuroscience, 2014 - Soc Neuroscience
Although it is known that immune system activation can impair cognition, no study to date
has linked cognitive deficits during acute neuroinflammation to dysregulation of task …

Adult hippocampal neurogenesis for systems consolidation of memory

JI Terranova, SK Ogawa, T Kitamura - Behavioural brain research, 2019 - Elsevier
The hippocampus (HPC) is required for the initial process of permanent memory formation.
After memory acquisition, HPC-dependency of memory recall gradually decreases with time …

Role of adult neurogenesis in hippocampal-cortical memory consolidation

T Kitamura, K Inokuchi - Molecular brain, 2014 - Springer
Acquired memory is initially dependent on the hippocampus (HPC) for permanent memory
formation. This hippocampal dependency of memory recall progressively decays with time, a …