Adult hippocampal neurogenesis, fear generalization, and stress
The generalization of fear is an adaptive, behavioral, and physiological response to the
likelihood of threat in the environment. In contrast, the overgeneralization of fear, a cardinal …
likelihood of threat in the environment. In contrast, the overgeneralization of fear, a cardinal …
Context, emotion, and the strategic pursuit of goals: interactions among multiple brain systems controlling motivated behavior
AJ Gruber, RJ McDonald - Frontiers in behavioral neuroscience, 2012 - frontiersin.org
Motivated behavior exhibits properties that change with experience and partially dissociate
among a number of brain structures. Here, we review evidence from rodent experiments …
among a number of brain structures. Here, we review evidence from rodent experiments …
Optogenetic stimulation of a hippocampal engram activates fear memory recall
A specific memory is thought to be encoded by a sparse population of neurons,. These
neurons can be tagged during learning for subsequent identification and manipulation …
neurons can be tagged during learning for subsequent identification and manipulation …
Modulating neuronal competition dynamics in the dentate gyrus to rejuvenate aging memory circuits
KM McAvoy, KN Scobie, S Berger, C Russo, N Guo… - Neuron, 2016 - cell.com
The neural circuit mechanisms underlying the integration and functions of adult-born dentate
granule cell (DGCs) are poorly understood. Adult-born DGCs are thought to compete with …
granule cell (DGCs) are poorly understood. Adult-born DGCs are thought to compete with …
Disambiguating the similar: the dentate gyrus and pattern separation
B Schmidt, DF Marrone, EJ Markus - Behavioural brain research, 2012 - Elsevier
The human hippocampus supports the formation of episodic memory without confusing new
memories with old ones. To accomplish this, the brain must disambiguate memories (ie …
memories with old ones. To accomplish this, the brain must disambiguate memories (ie …
The transcription factor Zif268/Egr1, brain plasticity, and memory
The capacity to remember our past experiences and organize our future draws on a number
of cognitive processes that allow our brain to form and store neural representations that can …
of cognitive processes that allow our brain to form and store neural representations that can …
Adult neurogenesis in the mammalian hippocampus: why the dentate gyrus?
In the adult mammalian brain, newly generated neurons are continuously incorporated into
two networks: interneurons born in the subventricular zone migrate to the olfactory bulb …
two networks: interneurons born in the subventricular zone migrate to the olfactory bulb …
Acute neuroinflammation impairs context discrimination memory and disrupts pattern separation processes in hippocampus
J Czerniawski, JF Guzowski - Journal of Neuroscience, 2014 - Soc Neuroscience
Although it is known that immune system activation can impair cognition, no study to date
has linked cognitive deficits during acute neuroinflammation to dysregulation of task …
has linked cognitive deficits during acute neuroinflammation to dysregulation of task …
Adult hippocampal neurogenesis for systems consolidation of memory
The hippocampus (HPC) is required for the initial process of permanent memory formation.
After memory acquisition, HPC-dependency of memory recall gradually decreases with time …
After memory acquisition, HPC-dependency of memory recall gradually decreases with time …
Role of adult neurogenesis in hippocampal-cortical memory consolidation
T Kitamura, K Inokuchi - Molecular brain, 2014 - Springer
Acquired memory is initially dependent on the hippocampus (HPC) for permanent memory
formation. This hippocampal dependency of memory recall progressively decays with time, a …
formation. This hippocampal dependency of memory recall progressively decays with time, a …