Scopoletin is a coumarin synthesized by diverse medicinal and edible plants, which plays a
vital role as a therapeutic and chemopreventive agent in the treatment of a variety of …

Quercetin has been identified as a promising compound with a neuroprotective potential
against age-related neurodegenerative diseases such as Alzheimer's disease (AD) …

Background: Alzheimer's disease (AD) is an advanced and irreversible degenerative
disease of the brain, recognized as the key reason for dementia among elderly people. The …

A series of diaryl ethers were synthesized and their human (h) carbonic anhydrase (CA)
isoenzymes hCA I and II, acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) …

We have designed a series of tacrine-based homo-and heterodimers that incorporate an
antioxidant tether (selenoureido, chalcogenide) as new dual compounds: for the treatment of …

A novel series of tacrine-bifendate (THA-DDB) conjugates (7a-e) were synthesized and
evaluated as potential anti-Alzheimer's agents. These compounds showed potent …

A new series of 4-dimethylamine flavonoid derivatives were designed and synthesized as
potential multifunctional anti-Alzheimer agents. The inhibition of cholinesterase activity, self …

(1) Background: Scopoletin and scoparone, two naturally occurring coumarins, have
garnered considerable attention and have been introduced to the market in China due to …

Herein we report the synthesis of N-alkylated deoxynojirimycin derivatives decorated with a
selenoureido motif at the hydrocarbon tether as an example of unprecedented multitarget …

A new series of benzotriazole-derived α-substituted hemiaminal ethers have been
synthesized as human cholinesterase (hChE) inhibitors with enhanced activity. The …