Drugs for autoimmune inflammatory diseases: from small molecule compounds to anti-TNF biologics

P Li, Y Zheng, X Chen - Frontiers in pharmacology, 2017 - frontiersin.org
Although initially described as an anti-tumor mediator, tumor necrosis factor-alpha (TNF) is
generally considered as the master pro-inflammatory cytokine. It plays a crucial role in the …

[HTML][HTML] Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii

EJ Van Schaik, C Chen, K Mertens… - Nature Reviews …, 2013 - nature.com
The agent of Q fever, Coxiella burnetii, is an obligate intracellular bacterium that causes
acute and chronic infections. The study of C. burnetii pathogenesis has benefited from two …

MicroRNA-155 promotes autophagy to eliminate intracellular mycobacteria by targeting Rheb

J Wang, K Yang, L Zhou, null MinhaoWu, Y Wu… - PLoS …, 2013 - journals.plos.org
Mycobacterium tuberculosis is a hard-to-eradicate intracellular pathogen that infects one-
third of the global population. It can live within macrophages owning to its ability to arrest …

Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages

MY Park, HJ Kwon, MK Sung - Bioscience, biotechnology, and …, 2009 - academic.oup.com
The aloe ingredients responsible for physiological effects and the concentrations required to
exert their biological activities are not fully understood. This study compares the anti …

TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation

E Iizasa, Y Chuma, T Uematsu, M Kubota… - Nature …, 2021 - nature.com
Mycobacterial cell-wall glycolipids elicit an anti-mycobacterial immune response via FcRγ-
associated C-type lectin receptors, including Mincle, and caspase-recruitment domain family …

Anti-inflammatory activity of c-phycocyanin in lipopolysaccharide-stimulated RAW 264.7 macrophages

SC Cherng, SN Cheng, A Tarn, TC Chou - Life sciences, 2007 - Elsevier
C-phycocyanin (C-PC), found in blue green algae, is often used as a dietary nutritional
supplement. C-PC has been found to have an anti-inflammatory activity and exert beneficial …

IFN-γ-induced TNF-α expression is regulated by interferon regulatory factors 1 and 8 in mouse macrophages

V Vila-del Sol, C Punzon, M Fresno - The Journal of Immunology, 2008 - journals.aai.org
We have previously described that IFN-γ induces cyclooxygenase 2 and inducible NO
synthase expression by a mechanism that involved endogenously produced TNF-α. In this …

IFN-γ deficiency attenuates hepatic inflammation and fibrosis in a steatohepatitis model induced by a methionine-and choline-deficient high-fat diet

XY Luo, T Takahara, K Kawai… - American Journal …, 2013 - journals.physiology.org
Cytokines play important roles in all stages of steatohepatitis, including hepatocyte injury,
the inflammatory response, and the altered function of sinusoidal cells. This study examined …

Serum amyloid A induction of cytokines in monocytes/macrophages and lymphocytes

C Song, K Hsu, E Yamen, W Yan, J Fock, PK Witting… - Atherosclerosis, 2009 - Elsevier
OBJECTIVES: Serum amyloid A (SAA) is a biomarker of inflammation. Elevated blood levels
in cardiovascular disease and local deposition in atheroma implies a role of SAA as a …

Royal jelly acid, 10-hydroxy-trans-2-decenoic acid, as a modulator of the innate immune responses

T Sugiyama, K Takahashi, H Mori - Endocrine, Metabolic & …, 2012 - ingentaconnect.com
Royal jelly is a food for queen and larvae honeybees. 10-Hydroxy-trans-2-decenoic acid
(10H2DA;“royal jelly acid”) is the principal lipid component in royal jelly. Several …