Abstract Poly (ADP-ribose)(PAR) polymerase-1 (PARP-1) acts as a DNA damage sensor. It
recognizes DNA damage and facilitates DNA repair by recruiting DNA repair machinery to …

DNA2 nuclease/helicase is a structure-specific nuclease, 5′-to-3′ helicase, and DNA-
dependent ATPase. It is involved in multiple DNA metabolic pathways, including Okazaki …

The breast cancer susceptibility proteins BRCA1 and BRCA2 have emerged as key
stabilizing factors for the maintenance of replication fork integrity following replication stress …

Homologous recombination (HR) and Fanconi Anemia (FA) pathway proteins in addition to
their DNA repair functions, limit nuclease-mediated processing of stalled replication forks …

Since the discovery of the DNA double helix, there has been a fascination in understanding
the molecular mechanisms and cellular processes that account for:(i) the transmission of …

With the urgent need for bio-nanomaterials to improve the currently available cancer
treatments, gold nanoparticle (GNP) hybrid nanostructures are rapidly rising as promising …

RIF1 is a multifunctional protein implicated in controlling DNA replication and repair. Here,
we show that human RIF1 protects nascent DNA from over-degradation at stalled replication …

Small molecules that deter the functions of DNA damage response machinery are
postulated to be useful for enhancing the DNA damaging effects of chemotherapy or ionizing …

This article reviews the currently used therapeutic strategies to target DNA replication stress
for cancer treatment in the clinic, highlighting their effectiveness and limitations due to …

Joint DNA molecules are natural byproducts of DNA replication and repair. Persistent joint
molecules give rise to ultrafine DNA bridges (UFBs) in mitosis, compromising sister …