Interaction of the host and viral genome and their influence on HIV disease
RH Tough, PJ McLaren - Frontiers in Genetics, 2019 - frontiersin.org
The course of Human Immunodeficiency Virus type 1 (HIV) infection is a dynamic interplay in
which both host and viral genetic variation, among other factors, influence disease …
which both host and viral genetic variation, among other factors, influence disease …
[HTML][HTML] Generation of a novel SARS-CoV-2 sub-genomic RNA due to the R203K/G204R variant in nucleocapsid: homologous recombination has potential to change …
Background: Genetic variations across the SARS-CoV-2 genome may influence
transmissibility of the virus and the host's anti-viral immune response, in turn affecting the …
transmissibility of the virus and the host's anti-viral immune response, in turn affecting the …
Clinical and evolutionary consequences of HIV adaptation to HLA: implications for vaccine and cure
Clinical and evolutionary consequences of HIV adaptation to... : Current Opinion in HIV and
AIDS Clinical and evolutionary consequences of HIV adaptation to HLA: implications for …
AIDS Clinical and evolutionary consequences of HIV adaptation to HLA: implications for …
Deep sequence analysis of HIV adaptation following vertical transmission reveals the impact of immune pressure on the evolution of HIV
Human immunodeficiency virus (HIV) can adapt to an individual's T cell immune response
via genomic mutations that affect antigen recognition and impact disease outcome. These …
via genomic mutations that affect antigen recognition and impact disease outcome. These …
[PDF][PDF] Three adjacent nucleotide changes spanning two residues in SARS-CoV-2 nucleoprotein: possible homologous recombination from the transcription-regulating …
The COVID-19 pandemic is caused by the single-stranded RNA virus severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), a virus of zoonotic origin that was first …
respiratory syndrome coronavirus 2 (SARS-CoV-2), a virus of zoonotic origin that was first …
High level of pre-treatment HIV-1 drug resistance and its association with HLA Class I-mediated restriction in the Pumwani sex worker cohort
R Willim, E Shadabi, R Sampathkumar, L Li, R Balshaw… - Viruses, 2022 - mdpi.com
Background: We analyzed the prevalence of pre-antiretroviral therapy (ART) drug resistance
mutations (DRMs) in a Kenyan population. We also examined whether host HLA class I …
mutations (DRMs) in a Kenyan population. We also examined whether host HLA class I …
APOBEC3G regulation of the evolutionary race between adaptive immunity and viral immune escape is deeply imprinted in the HIV genome
F Borzooee, KD Joris, MD Grant, M Larijani - Frontiers in immunology, 2019 - frontiersin.org
APOBEC3G (A3G) is a host enzyme that mutates the genomes of retroviruses like HIV. Since
A3G is expressed pre-infection, it has classically been considered an agent of innate …
A3G is expressed pre-infection, it has classically been considered an agent of innate …
Action needed to address molecular HIV surveillance ethical concerns
There have been growing ethical concerns about the widespread use of HIV-related
molecular epidemiological public health surveillance and research—or what has come to be …
molecular epidemiological public health surveillance and research—or what has come to be …
Cross-Reactivity to Mutated Viral Immune Targets Can Influence CD8+ T Cell Functionality: An Alternative Viral Adaptation Strategy
Loss of T cell immunogenicity due to mutations in virally encoded epitopes is a well-
described adaptation strategy to limit host anti-viral immunity. Another described, but less …
described adaptation strategy to limit host anti-viral immunity. Another described, but less …
A principled approach to research conducted with Inuit, Métis, and first nations people: promoting engagement inspired by the CIHR guidelines for health research …
Research to address the health burdens experienced by Indigenous populations is
essential. In the Canadian context, the Truth and Reconciliation Commission of Canada …
essential. In the Canadian context, the Truth and Reconciliation Commission of Canada …