Evolutionary expansion and complexification of the primate cerebral cortex are largely
linked to the emergence of the outer subventricular zone (OSVZ), a uniquely structured …

The discovery of microRNAs (miRNAs) has added a new player to the regulation of gene
expression. With the increasing number of molecular species involved in gene regulatory …

MicroRNAs (miRNAs) are single-stranded, non-coding RNA molecules that play important
roles in the development and functions of the brain. Extensive studies have revealed critical …

The mammalian cerebral cortex is the pinnacle of brain evolution, reaching its maximum
complexity in terms of neuron number, diversity and functional circuitry. The emergence of …

In the fast lane of chronobiology, ultradian events are short-term rhythms that have been
observed since the beginning of modern biology and were quantified about a century ago …

Quiescent neural stem cells (NSCs) in the adult mouse brain are the source of neurogenesis
that regulates innate and adaptive behaviors. Adult NSCs in the subventricular zone are …

During embryogenesis cells make fate decisions within complex tissue environments. The
levels and dynamics of transcription factor expression regulate these decisions. Here, we …

One of the biggest mysteries in neurobiology concerns the mechanisms responsible for the
diversification of the brain over different time scales, ie during development and evolution …

Many cell-fate decisions during embryonic development are governed by a motif comprised
of two transcription factors (TFs) A and B that mutually inhibit each other and may self …

Canonical Notch signaling has diverse functions during nervous system development and is
critical for neural progenitor self-renewal, timing of differentiation and specification of various …