[HTML][HTML] Functional and mechanistic diversity of distal transcription enhancers
M Bulger, M Groudine - Cell, 2011 - cell.com
Biological differences among metazoans and between cell types in a given organism arise
in large part due to differences in gene expression patterns. Gene-distal enhancers are key …
in large part due to differences in gene expression patterns. Gene-distal enhancers are key …
The language of covalent histone modifications
BD Strahl, CD Allis - Nature, 2000 - nature.com
Histone proteins and the nucleosomes they form with DNA are the fundamental building
blocks of eukaryotic chromatin. A diverse array of post-translational modifications that often …
blocks of eukaryotic chromatin. A diverse array of post-translational modifications that often …
Histone acetyltransferases
▪ Abstract Transcriptional regulation in eukaryotes occurs within a chromatin setting and is
strongly influenced by nucleosomal barriers imposed by histone proteins. Among the well …
strongly influenced by nucleosomal barriers imposed by histone proteins. Among the well …
The coregulator exchange in transcriptional functions of nuclear receptors
CK Glass, MG Rosenfeld - Genes & development, 2000 - genesdev.cshlp.org
Nuclear receptors (NR) comprise a family of transcription factors that regulate gene
expression in a liganddependent manner. Members of the NR superfamily include receptors …
expression in a liganddependent manner. Members of the NR superfamily include receptors …
Histone acetylation and an epigenetic code
BM Turner - Bioessays, 2000 - Wiley Online Library
The enzyme‐catalyzed acetylation of the N‐terminal tail domains of core histones provides a
rich potential source of epigenetic information. This may be used both to mediate transient …
rich potential source of epigenetic information. This may be used both to mediate transient …
Cooperation between complexes that regulate chromatin structure and transcription
Chromatin structure creates barriers for each step in eukaryotic transcription. Here we
discuss how the activities of two major classes of chromatin-modifying complexes, ATP …
discuss how the activities of two major classes of chromatin-modifying complexes, ATP …
Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation
VM Richon, TW Sandhoff… - Proceedings of the …, 2000 - National Acad Sciences
Histone deacetylases (HDACs) catalyze the removal of acetyl groups on the amino-terminal
lysine residues of core nucleosomal histones. This activity is associated generally with …
lysine residues of core nucleosomal histones. This activity is associated generally with …
Androgen receptor (AR) coregulators: an overview
CA Heinlein, C Chang - Endocrine reviews, 2002 - academic.oup.com
The biological action of androgens is mediated through the androgen receptor (AR).
Androgen-bound AR functions as a transcription factor to regulate genes involved in an …
Androgen-bound AR functions as a transcription factor to regulate genes involved in an …
CREB-binding protein and p300 in transcriptional regulation
N Vo, RH Goodman - Journal of Biological Chemistry, 2001 - ASBMB
CREB1-binding protein (CBP) and p300 are believed to participate in the activities of
hundreds of different transcription factors (see Fig. 1). Current models suggest that the …
hundreds of different transcription factors (see Fig. 1). Current models suggest that the …