Biological differences among metazoans and between cell types in a given organism arise
in large part due to differences in gene expression patterns. Gene-distal enhancers are key …

Histone proteins and the nucleosomes they form with DNA are the fundamental building
blocks of eukaryotic chromatin. A diverse array of post-translational modifications that often …

▪ Abstract Transcriptional regulation in eukaryotes occurs within a chromatin setting and is
strongly influenced by nucleosomal barriers imposed by histone proteins. Among the well …

Nuclear receptors (NR) comprise a family of transcription factors that regulate gene
expression in a liganddependent manner. Members of the NR superfamily include receptors …

The enzyme‐catalyzed acetylation of the N‐terminal tail domains of core histones provides a
rich potential source of epigenetic information. This may be used both to mediate transient …

Chromatin structure creates barriers for each step in eukaryotic transcription. Here we
discuss how the activities of two major classes of chromatin-modifying complexes, ATP …

Histone deacetylases (HDACs) catalyze the removal of acetyl groups on the amino-terminal
lysine residues of core nucleosomal histones. This activity is associated generally with …

The biological action of androgens is mediated through the androgen receptor (AR).
Androgen-bound AR functions as a transcription factor to regulate genes involved in an …

CREB1-binding protein (CBP) and p300 are believed to participate in the activities of
hundreds of different transcription factors (see Fig. 1). Current models suggest that the …

Understanding the mechanisms by which chromatin structure controls eukaryotic
transcription has been an intense area of investigation for the past 25 years. Many of the key …