Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-
tumor and anti-viral responses, and therefore possess promising clinical utilization. NK cells …

Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune
response. Although it was initially linked with the development of Th1 responses, it is now …

Multiple sclerosis (MS) is a frequent autoimmune demyelinating disease of the central
nervous system (CNS). There are three clinical forms described: relapsing-remitting multiple …

Natural killer (NK) cells are characterized by their ability to detect and induce apoptosis of
susceptible target cells and by secretion of immunoregulatory cytokines such as IFN-γ …

Recent studies suggested that human CD56 bright CD16− NK cells may play a role in the
regulation of the immune response. Since the mechanism (s) involved have not yet been …

CD38 is a multifunctional cell surface protein endowed with receptor/enzymatic functions.
The protein is generally expressed at low/intermediate levels on hematological tissues and …

Background Natural killer (NK) cells are an emerging new tool for cancer immunotherapy.
To develop NK cell therapeutics from peripheral blood mononuclear cells (PBMCs) of …

The tumor microenvironment (TME) is jointly constructed by a variety of cell types, including
tumor cells, immune cells, fibroblasts, and epithelial cells, among others. The cells within the …

Natural killer (NK)-cells are major players in the fight against viral infections and transformed
cells, but there is increasing evidence attributing a disease-promoting role to NK-cells …