In the past 20 years, our understanding of the pathophysiology of depression has evolved
from a focus on an imbalance of monoaminergic neurotransmitters to a multifactorial picture …

α5 subunit containing GABA type A receptors (GABAARs) have long been an enigmatic
receptor subtype of interest due to their specific brain distribution, unusual surface …

At the present time, no viable treatment exists for cognitive and olfactory deficits in Down
syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive …

Down syndrome (DS) is a neurological disorder with multiple immune-related symptoms;
however, crosstalk between the CNS and peripheral immune system remains unexplored …

Synaptic plasticity is a critical process that regulates neuronal activity by allowing neurons to
adjust their synaptic strength in response to changes in activity. Despite the high proximity of …

Dysregulation of insulin signaling pathway with reduced downstream neuronal survival and
plasticity mechanisms is a fundamental abnormality observed in Alzheimer's disease (AD) …

Down syndrome (DS) results in various degrees of cognitive deficits. In DS mouse models,
recovery of behavioral and neurophysiological deficits using GABAAR antagonists led to …

In the neocortex, fast synaptic inhibition orchestrates both spontaneous and sensory-evoked
activity. GABAergic interneurons (INs) inhibit pyramidal neurons (PNs) directly, modulating …

In the last decade, an important effort was made in the field of Down syndrome to find new
interventions that improve cognition. These therapies have added to the traditional …

Transforming growth factor-β1 (TGF-β1), a multifunctional cytokine, plays a pivotal role in
synaptic formation, plasticity, and neurovascular unit regulation. This review highlights TGF …