Naturally produced halogenated compounds are ubiquitous across all domains of life where
they perform a multitude of biological functions and adopt a diversity of chemical structures …

Nature has evolved halogenase enzymes to regioselectively halogenate a diverse range of
biosynthetic precursors, with the halogens introduced often having a profound effect on the …

Monoterpenoid indole alkaloids (MIAs) represent a large class of plant natural products with
marketed pharmaceutical activities against a wide range of indications, including cancer …

Flavoprotein monooxygenases (FPMOs) are single-or two-component enzymes that
catalyze a diverse set of chemo-, regio-and enantioselective oxyfunctionalization reactions …

Freestanding nonproteinogenic amino acids have long been recognized for their
antimetabolite properties and tendency to be uncovered to reactive functionalities by the …

During the last decades a large number of flavin-dependent monooxygenases have been
isolated and studied. This has revealed that flavoprotein monooxygenases are able to …

Covering: up to the end of May 2012 Riboflavin-based coenzymes, tightly bound to enzymes
catalyzing substrate oxidations and reductions, enable an enormous range of chemical …

Halogenated molecules are widely distributed in the biosphere. A variety of halogenated
aromatic and aliphatic compounds are man-made and can be harmful to the environment …

Covering: up to May 2006. This Highlight provides an overview of the molecular logic
employed in the formation and elaboration of pyrroles during natural product biosyntheses …

Covering: up to June 2006 The indolocarbazole family of natural products, including the
biosynthetically related bisindolylmaleimides, is reviewed (with 316 references cited). The …