Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …

While scientific advances have led to large-scale production and widespread distribution of
vaccines and antiviral drugs, viruses still remain a major cause of human diseases today …

This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

Many proteins exert their biological activities through small exposed surface regions called
epitopes that are folded peptides of well‐defined three‐dimensional structures. Short …

Antimicrobial peptides (AMPs) attracted attention as potential source of novel antimicrobials.
Multi-drug resistant (MDR) infections have emerged as a global threat to public health in …

Despite rapid advances in the human healthcare, the infection caused by certain viruses
results in high morbidity and mortality accentuate the importance for development of new …

Plants evolve to synthesize various natural metabolites to protect themselves against
threats, such as insects, predators, microorganisms, and environmental conditions (such as …

Cell-penetrating peptides can translocate across the plasma membrane of living cells and
thus are potentially useful agents in drug delivery applications. Disulfide-rich cyclic peptides …

Cancer mortality and morbidity is projected to increase significantly over the next few
decades. Current chemotherapeutic strategies have significant limitations, and there is great …

Cyclotides are plant-derived cyclic peptides that have a head-to-tail cyclic backbone and
three conserved disulphide bonds that form a cyclic cystine knot motif. They occur in plants …