Liver fibrosis accompanies the progression of chronic liver diseases independent of
etiologies, such as hepatitis viral infection, alcohol consumption, and metabolic-associated …

A high-fat diet (HFD) causes hyperlipidemia, which worsens disturbances in bile acid (BA)
metabolism and gut microbiota. This study aimed to investigate the regulation of flavonoids …

Bile acids, the endogenous steroid nucleus containing signaling molecules, are responsible
for the regulation of multiple metabolic processes, including lipoprotein and glucose …

Basic and clinical studies have continued to discover novel roles of the enterohepatic bile
acid signaling in regulation of key metabolic pathways. Such knowledge forms the molecular …

Cholestasis is a key causative factor in alcohol-related liver disease (ALD) and variable
degrees of cholestasis occur in all stages of ALD. However, the pathogenetic mechanisms …

Background & Aims Intestine-restricted inhibitors of the apical sodium-dependent bile acid
transporter (ASBT, or ileal bile acid transporter) are approved as treatment for several …

“A healthy liver stands on a healthy gut” with the gut and its barriers representing the roots
that fuel the liver and expose it to an amazing diverse mixture of gut-derived material/agents …

Bile acid (BA) metabolism is an attractive therapeutic target in nonalcoholic fatty liver
disease (NAFLD). We aimed to investigate the effect of ilexsaponin A1 (IsA), a major …

Therapeutic reduction of hydrophobic bile acids exposure is considered beneficial in
cholestasis. The Cyp2c70 KO mice lack hydrophilic muricholic acids and have a human-like …

Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis
accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile …