The progress in understanding and treatment of diabetic retinopathy

AW Stitt, TM Curtis, M Chen, RJ Medina… - Progress in retinal and …, 2016 - Elsevier
Diabetic retinopathy is the most frequently occurring complication of diabetes mellitus and
remains a leading cause of vision loss globally. Its aetiology and pathology have been …

New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism

S Eid, KM Sas, SF Abcouwer, EL Feldman, TW Gardner… - Diabetologia, 2019 - Springer
Diabetes adversely affects multiple organs, including the kidney, eye and nerve, leading to
diabetic kidney disease, diabetic retinopathy and diabetic neuropathy, respectively. In both …

Wnt Signaling in vascular eye diseases

Z Wang, CH Liu, S Huang, J Chen - Progress in retinal and eye research, 2019 - Elsevier
The Wnt signaling pathway plays a pivotal role in vascular morphogenesis in various organs
including the eye. Wnt ligands and receptors are key regulators of ocular angiogenesis both …

Lipid metabolism dysregulation in diabetic retinopathy

JV Busik - Journal of lipid research, 2021 - ASBMB
Lipid metabolic abnormalities have emerged as potential risk factors for the development
and progression of diabetic complications, including diabetic retinopathy (DR). This review …

Pathogenic Role of microRNA-21 in Diabetic Retinopathy Through Downregulation of PPARα

Q Chen, F Qiu, K Zhou, HG Matlock, Y Takahashi… - Diabetes, 2017 - Am Diabetes Assoc
Fenofibrate, a specific agonist of peroxisome proliferator–activated receptor-α (PPARα),
displays robust therapeutic effects on diabetic retinopathy (DR) in patients with type 2 …

Pericytes, inflammation, and diabetic retinopathy

BG Spencer, JJ Estevez, E Liu, JE Craig… - …, 2020 - Springer
Diabetic retinopathy (DR) is a frequent complication of diabetes mellitus, and a common
cause of vision impairment and blindness in these patients, yet many aspects of its …

Vascular pericyte impairment and connexin43 gap junction deficit contribute to vasomotor decline in diabetic retinopathy

E Ivanova, T Kovacs-Oller… - Journal of …, 2017 - Soc Neuroscience
Adequate blood flow is essential to brain function, and its disruption is an early indicator in
diseases, such as stroke and diabetes. However, the mechanisms contributing to this …

Fenofibrate ameliorates diabetic retinopathy by modulating Nrf2 signaling and NLRP3 inflammasome activation

Q Liu, F Zhang, X Zhang, R Cheng, J Ma, J Yi… - Molecular and Cellular …, 2018 - Springer
Oxidative stress and neuroinflammation contribute significantly to the development and
progression of diabetic retinopathy. Fenofibrate has received great attention as it benefits …

The Effect of Hyperlipidemia on the Course of Diabetic Retinopathy—Literature Review

A Bryl, M Mrugacz, M Falkowski, K Zorena - Journal of clinical medicine, 2022 - mdpi.com
Diabetes mellitus is a very important social issue, and its retinal complications continue to be
one of the major causes of blindness worldwide. The effect of glucose level on the …

Peroxisome proliferator-activated receptor-α (PPARα) regulates wound healing and mitochondrial metabolism in the cornea

W Liang, L Huang, A Whelchel… - Proceedings of the …, 2023 - National Acad Sciences
Diabetes can result in impaired corneal wound healing. Mitochondrial dysfunction plays an
important role in diabetic complications. However, the regulation of mitochondria function in …