Robust phenotyping of highly multiplexed tissue imaging data using pixel-level clustering
While technologies for multiplexed imaging have provided an unprecedented understanding
of tissue composition in health and disease, interpreting this data remains a significant …
of tissue composition in health and disease, interpreting this data remains a significant …
[HTML][HTML] Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein …
AC Stoll, CJ Kemp, JR Patterson, JW Howe… - Neurobiology of …, 2024 - Elsevier
Parkinson's disease (PD) pathology is characterized by alpha-synuclein (α-syn) aggregates,
degeneration of dopamine neurons in the substantia nigra pars compacta (SNpc), and …
degeneration of dopamine neurons in the substantia nigra pars compacta (SNpc), and …
Extracellular vesicles released from microglia after palmitate exposure impact brain function
GC De Paula, BI Aldana, R Battistella… - Journal of …, 2024 - Springer
Dietary patterns that include an excess of foods rich in saturated fat are associated with
brain dysfunction. Although microgliosis has been proposed to play a key role in the …
brain dysfunction. Although microgliosis has been proposed to play a key role in the …
Microgliosis driven by palmitate exposure alters energy metabolism and extracellular vesicles release that impact behavior and systemic metabolism
GC De Paula, B Aldana, R Battistella… - bioRxiv, 2024 - biorxiv.org
Dietary patterns that include an excess of foods rich in saturated fat are associated with
brain dysfunction. Although microgliosis has been proposed to play a key role in the …
brain dysfunction. Although microgliosis has been proposed to play a key role in the …
The autophagy proteome in the brain
VI Ito‐Silva, BJ Smith… - Journal of Neurochemistry - Wiley Online Library
As one of the most important cellular housekeepers, autophagy directly affects cellular
health, homeostasis, and function. Even though the mechanisms behind autophagy are well …
health, homeostasis, and function. Even though the mechanisms behind autophagy are well …