Harnessing the process of natural selection to obtain and understand new microbial
phenotypes has become increasingly possible due to advances in culturing techniques …

In experimental evolution, laboratory-controlled conditions select for the adaptation of
species, which can be monitored in real time. Despite the current popularity of such …

The outcomes of evolution are determined by a stochastic dynamical process that governs
how mutations arise and spread through a population. However, it is difficult to observe …

Adaptation by natural selection depends on the rates, effects and interactions of many
mutations, making it difficult to determine what proportion of mutations in an evolving lineage …

Can a heterotrophic organism be evolved to synthesize biomass from CO 2 directly? So far,
non-native carbon fixation in which biomass precursors are synthesized solely from CO 2 …

Precise control over microbial cell growth conditions could enable detection of minute
phenotypic changes, which would improve our understanding of how genotypes are shaped …

Evolutionary game theory is a successful mathematical framework geared towards
understanding the selective pressures that affect the evolution of the strategies of agents …

Evolution is an on-going process, and it can be studied experimentally in organisms with
rapid generations. My team has maintained 12 populations of Escherichia coli in a simple …

Biofilms are a major form of microbial life in which cells form dense surface associated
communities that can persist for many generations. The long-life of biofilm communities …

Heterogeneity in strategies for survival and proliferation among the cells that constitute a
tumour is a driving force behind the evolution of resistance to cancer therapy. The rules …