Recent progress in Lyme disease and remaining challenges

JR Bobe, BL Jutras, EJ Horn, ME Embers… - Frontiers in …, 2021 - frontiersin.org
Lyme disease (also known as Lyme borreliosis) is the most common vector-borne disease in
the United States with an estimated 476,000 cases per year. While historically, the long-term …

Current and future molecular diagnostics of tick-borne diseases in cattle

K Garcia, M Weakley, T Do, S Mir - Veterinary Sciences, 2022 - mdpi.com
Ticks and tick-borne diseases such as babesiosis, anaplasmosis, ehrlichiosis, Lyme
disease, Crimean Congo hemorrhagic fever, and Rocky Mountain spotted fever pose a …

Tickborne diseases—confronting a growing threat

CI Paules, HD Marston, ME Bloom… - New England Journal of …, 2018 - Mass Medical Soc
Tickborne Diseases — Confronting a Growing Threat | New England Journal of Medicine Skip to
main content The New England Journal of Medicine homepage Advanced Search SEARCH …

Antibodies to enteroviruses in cerebrospinal fluid of patients with acute flaccid myelitis

N Mishra, TFF Ng, RL Marine, K Jain, J Ng, R Thakkar… - MBio, 2019 - Am Soc Microbiol
Acute flaccid myelitis (AFM) has caused motor paralysis in> 560 children in the United
States since 2014. The temporal association of enterovirus (EV) outbreaks with increases in …

Immunoreactive peptide maps of SARS-CoV-2

N Mishra, X Huang, S Joshi, C Guo, J Ng… - Communications …, 2021 - nature.com
Serodiagnosis of SARS-CoV-2 infection is impeded by immunological cross-reactivity
among the human coronaviruses (HCoVs): SARS-CoV-2, SARS-CoV-1, MERS-CoV, OC43 …

PepSeq: a fully in vitro platform for highly multiplexed serology using customizable DNA-barcoded peptide libraries

SN Henson, EA Elko, PM Swiderski, Y Liang… - Nature protocols, 2023 - nature.com
PepSeq is an in vitro platform for building and conducting highly multiplexed proteomic
assays against customizable targets by using DNA-barcoded peptides. Starting with a pool …

Discovery and surveillance of tick-borne pathogens

R Tokarz, WI Lipkin - Journal of Medical Entomology, 2021 - academic.oup.com
Within the past 30 yr molecular assays have largely supplanted classical methods for
detection of tick-borne agents. Enhancements provided by molecular assays, including …

Rapid response to pandemic threats: immunogenic epitope detection of pandemic pathogens for diagnostics and vaccine development using peptide microarrays

K Heiss, J Heidepriem, N Fischer… - Journal of proteome …, 2020 - ACS Publications
Emergence and re-emergence of pathogens bearing the risk of becoming a pandemic threat
are on the rise. Increased travel and trade, growing population density, changes in …

Antibody epitope repertoire analysis enables rapid antigen discovery and multiplex serology

K Kamath, J Reifert, T Johnston, C Gable… - Scientific reports, 2020 - nature.com
The detection of pathogen-specific antibodies remains a cornerstone of clinical diagnostics.
Yet, many test exhibit undesirable performance or are completely lacking. Given this, we …

Parasitologist-level classification of apicomplexan parasites and host cell with deep cycle transfer learning (DCTL)

S Li, Q Yang, H Jiang, JA Cortés-Vecino… - …, 2020 - academic.oup.com
Abstract Motivation Apicomplexan parasites, including Toxoplasma, Plasmodium and
Babesia, are important pathogens that affect billions of humans and animals worldwide …