Current trends in health-promoting potential and biomaterial applications of edible mushrooms for human wellness
Edible mushrooms are ubiquitous around the world due to their enormous health benefits.
Mushrooms have been used as folk medicine and healthy food from ancient times but their …
Mushrooms have been used as folk medicine and healthy food from ancient times but their …
New progresses on cell surface protein HSPA5/BiP/GRP78 in cancers and COVID-19
T Li, J Fu, J Cheng, AA Elfiky, C Wei, J Fu - Frontiers in Immunology, 2023 - frontiersin.org
Heat-shock-protein family A (Hsp70) member 5 (HSPA5), aliases GRP78 or BiP, is a protein
encoded with 654 amino acids by the HSPA5 gene located on human chromosome 9q33. 3 …
encoded with 654 amino acids by the HSPA5 gene located on human chromosome 9q33. 3 …
How helpful were molecular dynamics simulations in shaping our understanding of SARS-CoV-2 spike protein dynamics?
The SARS-CoV-2 spike protein (S) represents an important viral component that is required
for successful viral infection in humans owing to its essential role in recognition of and entry …
for successful viral infection in humans owing to its essential role in recognition of and entry …
SARS-CoV-2 delta variant is recognized through GRP78 host-cell surface receptor, in silico perspective
Different SARS-CoV-2 new variants emerged and spread during the past few months,
sparking infections and death counts. The new variant B. 1.617 (delta variant) sparked in …
sparking infections and death counts. The new variant B. 1.617 (delta variant) sparked in …
Anti-breast cancer drugs targeting cell-surface glucose-regulated protein 78: a drug repositioning in silico study
Breast cancer (BC) is prevalent worldwide and is a leading cause of death among women.
However, cell-surface glucose-regulated protein 78 (cs-GRP78) is overexpressed in several …
However, cell-surface glucose-regulated protein 78 (cs-GRP78) is overexpressed in several …
Cs-GRP78 Recognition Site on Dengue Virus Envelope Protein: in silico perspective
AA Elfiky, A Amr, A Mosaad, AK Mubarak… - Future …, 2023 - Taylor & Francis
Aim: To understand the binding of the dengue virus (DENV) envelope and the host cell
factor, GRP78. Materials & methods: In this study, we simulate the binding of the DENV …
factor, GRP78. Materials & methods: In this study, we simulate the binding of the DENV …
In silico structural elucidation of Nipah virus L protein and targeting RNA-dependent RNA polymerase domain by nucleoside analogs
JM Abduljalil, AA Elfiky, ESTA Sayed… - Journal of …, 2023 - Taylor & Francis
The large (L) protein of Mononegavirales is a multi-domain protein that performs
transcription and genome replication. One of the important domains in L is the RNA …
transcription and genome replication. One of the important domains in L is the RNA …
Effect of temperature and nucleotide on the binding of BiP chaperone to a protein substrate
BiP (immunoglobulin heavy‐chain binding protein) is a Hsp70 monomeric ATPase motor
that plays broad and crucial roles in maintaining proteostasis inside the cell. Structurally, BiP …
that plays broad and crucial roles in maintaining proteostasis inside the cell. Structurally, BiP …
In silico targeting of SARS-CoV-2 spike receptor-binding domain from different variants with chaga mushroom terpenoids
Terpenoids from the chaga mushroom have been identified as potential antiviral agents
against SARS-CoV-2. This is because it can firmly bind to the viral spike receptor binding …
against SARS-CoV-2. This is because it can firmly bind to the viral spike receptor binding …
A computational approach to predict the possible binding site of HCV NS5A and the host cell chaperone, GRP78
Aim: Glucose-regulated protein 78 (GRP78) is an endoplasmic reticulum located chaperone
that plays a vital role during cellular stress. NS5A is one of the hepatitis C virus (HCV) non …
that plays a vital role during cellular stress. NS5A is one of the hepatitis C virus (HCV) non …