Mechanobiology studies the mechanisms by which cells sense and respond to physical
forces, and the role of these forces in shaping cells and tissues themselves …

Pannexin 1 (PANX1) is a widely expressed large-pore ion channel located in the plasma
membrane of almost all vertebrate cells. It possesses a unique ability to act as a conduit for …

Pannexin 1 (Panx1) is an ubiquitously expressed protein that forms plasma membrane
channels permeable to anions and moderate-sized signaling molecules (eg, ATP …

Chronic pain complicates many diseases and is notoriously difficult to treat. In search of new
therapeutic targets, pannexin-1 (Panx1) channels have sparked intense interest as a key …

The endoplasmic reticulum (ER) is the major intracellular calcium (Ca2+) storage
compartment in eukaryotic cells. In most instances, the mobilization of Ca2+ from this store is …

Endoplasmic reticulum-plasma membrane contact sites (ER-PM MCS) are a specialised
domain involved in the control of Ca 2+ dynamics and various Ca 2+-dependent cellular …

Background The opening of pannexin1 channels is considered as a key event in
inflammation. Pannexin1 channel-mediated release of adenosine triphosphate triggers …

Diacylglycerol kinase-ε (DGKε) catalyzes phosphorylation of diacylglycerol to phosphatidic
acid with a unique specificity toward 1-stearoyl-2-arachidonoyl-sn-glycerol, which is a …

Neurons are highly specialised cells that need to relay information over long distances and
integrate signals from thousands of synaptic inputs. The complexity of neuronal function is …

Epilepsy, a condition characterized by spontaneous recurrent epileptic seizures, is among
the most prevalent neurological disorders. This disorder is estimated to affect approximately …