Many different drugs and agents may cause nephrotoxic acute kidney injury (AKI) in
children. Predisposing factors such as age, pharmacogenetics, underlying disease, the …

Many physiologic differences between children and adults can result in age‐related
differences in pharmacokinetics. Understanding the effects of age on bioavailability, volume …

Management of high blood pressure in children and adolescent... : Journal of Hypertension
Management of high blood pressure in children and adolescents: recommendations of the …

Autosomal dominant polycystic kidney disease (ADPKD) is the most commonly inherited
kidney disease, characterized by progressive cyst growth and renal enlargement, resulting …

La hipertensión en niños y adolescentes ha ido ganando terreno en la medicina
cardiovascular, gracias a los avances producidos en distintas áreas de la investigación …

This 4‐week randomized, double blind, placebo‐controlled study (N= 240), 1‐year open
label trial (N= 233), and single‐dose pharmacokinetic study (N= 22) evaluated candesartan …

OBJECTIVES: Clinicians prescribe antihypertensive medication to children with primary
hypertension, but without data to define a particular choice as first-line therapy. A one-size …

BACKGROUND: The number of antihypertensive agents on the market has increased
dramatically over the past 20 years. Many of these agents are used to treat children and …

Background This study aimed to assess the pediatric lisinopril doses using an adult
physiological based pharmacokinetic (PBPK) model. As the empirical rules of dose …

Angiotensin‐converting enzyme (ACE) inhibitors are frequently used to treat hypertension in
children. 1 ACE inhibitors alter the balance between the vasoconstrictive, salt‐retentive, and …