The structure of neuronal circuits that subserve cognitive functions in the brain is shaped
and refined throughout development and into adulthood. Evidence from human and animal …

Schizophrenia is a neurodevelopmental disorder whose clinical features include
impairments in perception, cognition and motivation. These impairments reflect alterations in …

Schizophrenia is a chronic illness affecting approximately 0.5–1% of the world's population.
The etiology of schizophrenia is complex, including multiple genes, and contributing …

The mismatch negativity (MMN) component of the auditory event-related potential has
become a valuable tool in cognitive neuroscience. Its reduced size in persons with …

Psychiatric and neurodegenerative disorders, including intellectual disability, autism
spectrum disorders (ASD), schizophrenia (SZ), and Alzheimer's disease, pose an immense …

Background Microtubule-associated protein 2 (MAP2) is a neuronal protein that plays a role
in maintaining dendritic structure through its interaction with microtubules. In schizophrenia …

Synapses mediate information flow between neurons and undergo plastic changes in
response to experience, which is critical for learning and memory. Conversely, synaptic …

Changes in the actin cytoskeleton are a primary mechanism mediating the morphological
and functional plasticity that underlies learning and memory. The synaptic Ras homologous …

Synaptic plasticity represents the long lasting activity-related strengthening or weakening of
synaptic transmission, whose well-characterized types are the long term potentiation and …

Background Impaired glutamatergic signaling is believed to underlie auditory cortex
pyramidal neuron dendritic spine loss and auditory symptoms in schizophrenia. Many …