Is H3K4me3 instructive for transcription activation?
Tri‐methylation of lysine 4 on histone H3 (H3K4me3) is a near‐universal chromatin
modification at the transcription start site of active genes in eukaryotes from yeast to man …
modification at the transcription start site of active genes in eukaryotes from yeast to man …
SET for life: biochemical activities and biological functions of SET domain-containing proteins
HM Herz, A Garruss, A Shilatifard - Trends in biochemical sciences, 2013 - cell.com
SET domain-containing proteins belong to a group of enzymes named after a common
domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of …
domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of …
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
Abstract The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate
the genetic architecture and biology of heart, lung, blood and sleep disorders, with the …
the genetic architecture and biology of heart, lung, blood and sleep disorders, with the …
Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition
Epithelial-to-mesenchymal transition (EMT) is an extreme example of cell plasticity that is
important for normal development, injury repair and malignant progression. Widespread …
important for normal development, injury repair and malignant progression. Widespread …
Regulation of homologous recombination by RNF20-dependent H2B ubiquitination
K Nakamura, A Kato, J Kobayashi, H Yanagihara… - Molecular cell, 2011 - cell.com
The E3 ubiquitin ligase RNF20 regulates chromatin structure by monoubiquitinating histone
H2B in transcription. Here, we show that RNF20 is localized to double-stranded DNA breaks …
H2B in transcription. Here, we show that RNF20 is localized to double-stranded DNA breaks …
A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice
CC Pai, RS Deegan, L Subramanian, C Gal… - Nature …, 2014 - nature.com
DNA double-strand break (DSB) repair is a highly regulated process performed
predominantly by non-homologous end joining (NHEJ) or homologous recombination (HR) …
predominantly by non-homologous end joining (NHEJ) or homologous recombination (HR) …
Histone modifications and DNA double-strand break repair after exposure to ionizing radiations
CR Hunt, D Ramnarain, N Horikoshi… - Radiation …, 2013 - meridian.allenpress.com
Ionizing radiation exposure induces highly lethal DNA double-strand breaks (DSBs) in all
phases of the cell cycle. After DSBs are detected by the cellular machinery, these breaks are …
phases of the cell cycle. After DSBs are detected by the cellular machinery, these breaks are …
Histone methylation by SETD1A protects nascent DNA through the nucleosome chaperone activity of FANCD2
Components of the Fanconi anemia and homologous recombination pathways play a vital
role in protecting newly replicated DNA from uncontrolled nucleolytic degradation …
role in protecting newly replicated DNA from uncontrolled nucleolytic degradation …
H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ
R Bayley, V Borel, RJ Moss, E Sweatman, P Ruis… - Molecular Cell, 2022 - cell.com
Summary The 53BP1-RIF1-shieldin pathway maintains genome stability by suppressing
nucleolytic degradation of DNA ends at double-strand breaks (DSBs). Although RIF1 …
nucleolytic degradation of DNA ends at double-strand breaks (DSBs). Although RIF1 …
Preserving genome integrity and function: the DNA damage response and histone modifications
Modulation of chromatin templates in response to cellular cues, including DNA damage,
relies heavily on the post-translation modification of histones. Numerous types of histone …
relies heavily on the post-translation modification of histones. Numerous types of histone …