The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression

P Czarny, P Wigner, P Galecki, T Sliwinski - Progress in Neuro …, 2018 - Elsevier
A growing body of evidence suggests that inflammation, mitochondrial dysfunction and
oxidant-antioxidant imbalance may play a significant role in the development and …

Biomarkers and utility of the antioxidant potential of probiotic Lactobacilli and Bifidobacteria as representatives of the human gut microbiota

OV Averina, EU Poluektova, MV Marsova… - Biomedicines, 2021 - mdpi.com
Lactobacilli and bifidobacteria are an important part of human gut microbiota. Among
numerous benefits, their antioxidant properties are attracting more and more attention …

Air pollution, a rising environmental risk factor for cognition, neuroinflammation and neurodegeneration: The clinical impact on children and beyond

L Calderón-Garcidueñas, E Leray, P Heydarpour… - Revue …, 2016 - Elsevier
Air pollution (indoors and outdoors) is a major issue in public health as epidemiological
studies have highlighted its numerous detrimental health consequences (notably …

The roles of flavonols/flavonoids in neurodegeneration and neuroinflammation

Z Calis, R Mogulkoc, AK Baltaci - Mini Reviews in Medicinal …, 2020 - ingentaconnect.com
The inflammatory process in the human body is a physiological response involving many
cellular types and mediators. It results in scar formation to separate the damaged area from …

Neurobiological links between depression and AD: the role of TGF-β1 signaling as a new pharmacological target

F Caraci, SF Spampinato, MG Morgese… - Pharmacological …, 2018 - Elsevier
In the last several years a large number of studies have demonstrated the neurobiological
and clinical continuum between depression and Alzheimer's disease (AD). Depression is a …

Major depressive disorder and oxidative stress: a review of peripheral and genetic biomarkers according to clinical characteristics and disease stages

AEK Ait Tayeb, V Poinsignon, K Chappell, J Bouligand… - Antioxidants, 2023 - mdpi.com
Major depressive disorder (MDD) is currently the main cause of disability worldwide, but its
pathophysiology remains largely unknown, especially given its high heterogeneity in terms …

Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia?

S Piirainen, A Youssef, C Song, AV Kalueff… - Neuroscience & …, 2017 - Elsevier
Chronic psychosocial stress is increasingly recognized as a risk factor for late-onset
Alzheimer's disease (LOAD) and associated cognitive deficits. Chronic stress also primes …

Depression as a risk factor for Alzheimer's disease: Genes, steroids, cytokines and neurogenesis–What do we need to know?

J Herbert, PJ Lucassen - Frontiers in neuroendocrinology, 2016 - Elsevier
Depression (MDD) is prodromal to, and a component of, Alzheimer's disease (AD): it may
also be a trigger for incipient AD. MDD is not a unitary disorder, so there may be particular …

Discovery of a potent dual inhibitor of acetylcholinesterase and butyrylcholinesterase with antioxidant activity that alleviates Alzheimer-like pathology in old APP/PS1 …

E Viayna, N Coquelle… - Journal of Medicinal …, 2020 - ACS Publications
The combination of the scaffolds of the cholinesterase inhibitor huprine Y and the
antioxidant capsaicin results in compounds with nanomolar potencies toward human …

An EEG-fNIRS hybridization technique in the four-class classification of alzheimer's disease

PA Cicalese, R Li, MB Ahmadi, C Wang… - Journal of neuroscience …, 2020 - Elsevier
Background Alzheimer's disease (AD) is projected to become one of the most expensive
diseases in modern history, and yet diagnostic uncertainties exist that can only be confirmed …