This review describes the development of enantioselective methods for the ring opening of
cyclopropanes. Both approaches based on the reaction of nonchiral cyclopropanes and …

Three-and four-membered rings, widespread motifs in nature and medicinal chemistry, have
fascinated chemists ever since their discovery. However, due to energetic considerations …

In this review, synthetic and mechanistic aspects of key methodologies that exploit C–C
single-bond cleavage of strained ring systems are highlighted. The focus is on transition …

The transition-metal-catalyzed “cut and sew” transformation has recently emerged as a
useful strategy for preparing complex molecular structures. After oxidative addition of a …

The past decade has witnessed the golden age of homogeneous gold-catalyzed reactions,
especially those that involve the transformation of highly strained molecules into complex …

Complex natural products bearing strained cyclobutane subunits, including terpenoids,
alkaloids and steroids, not only display fascinating architectures, but also show potent …

This review summarizes synthetic developments reported from 1987 to 2019 that exploit C–
C single bond cleavage of cyclopropylamine-based systems. The synthetic and mechanistic …

Direct synthesis of gem‐difluorinated carbocyclic molecules represents a longstanding
challenge in organic chemistry. Herein, a Rh‐catalyzed [3+ 2] cycloaddition reaction …

Transition-metal-mediated carbon–carbon single-bond cleavage of cyclopropenes has been
widely exploited in organic synthesis. However, the ring-opening of cyclopropenes via the …

The synthesis of medium-sized lactams is a great challenge because of the unfavorable
transannular interactions and entropic barriers in the transition state. We have developed a …