Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been
studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable …

Cyclodextrin-based polymers (CDPs) are amphiphilic macromolecules owing to their unique
structure and the presence of multiple hydroxyl groups. These polymers have become …

Gene therapy by expression constructs or down-regulation of certain genes has shown great
potential for the treatment of various diseases. The wide clinical application of nucleic acid …

Cyclodextrins (CD) and derivatives are functional excipients that can improve the
bioavailability of numerous drugs. Because of their drug solubility improving properties they …

Abstract Interleukin 12 (IL12) is a potent pro‐inflammatory chemokine with multifunction,
including promoting cytotoxic T‐cell‐mediated killing of cancer cells. IL12‐based cancer …

The design and construction of polymers with diverse architectures play an important role in
the field of polymer science and offers new opportunities for the development of novel …

Cyclodextrins (CDs) are a series of cyclic oligosaccharides formed by amylose under the
action of CD glucosyltransferase that is produced by Bacillus. After being modified by …

Macrophages are abundant immune cells, which serve as a primary cell population capable
of interacting with foreign substances, including engineered nanomaterials (NMs). In …

Muscular dystrophies (MDs) are heterogeneous diseases, characterized by primary wasting
of skeletal muscle, which in severe cases, such as Duchenne Muscular Dystrophy (DMD) …

The low permeability of antifungal agents to fungal biofilms, which allows the continued
survival of the fungus inside, is a key issue that makes fungal infections difficult to cure …