Orexin-A regulates follicular growth, proliferation, cell cycle and apoptosis in mouse primary granulosa cells via the AKT/ERK signaling pathway

M Safdar, A Liang, SA Rajput, N Abbas, M Zubair… - Molecules, 2021 - mdpi.com
Granulosa cells (GCs) are essential for follicular growth, development, and atresia. The
orexin-A (OXA) neuropeptide is widely involved in the regulation of various biological …

The role of Melatonin receptor MTNR1A in the action of Melatonin on bovine granulosa cells

SJ Wang, WJ Liu, LK Wang, XS Pang… - Molecular …, 2017 - Wiley Online Library
Granulosa cells (GCs) play an important role in ovarian follicle growth, development, and
follicular atresia. In the present study, we investigated the effects of Melatonin on bovine …

The mechanism of melatonin and its receptor MT2 involved in the development of bovine granulosa cells

S Wang, W Liu, X Pang, S Dai, G Liu - International journal of molecular …, 2018 - mdpi.com
Ovarian granulosa cells (GCs) are a critical approach to investigate the mechanism of gene
regulation during folliculogenesis. The objective of this study was to investigate the role of …

Pituitary tumor suppression by combination of cabergoline and chloroquine

SJ Lin, ZR Wu, L Cao, Y Zhang, ZG Leng… - The Journal of …, 2017 - academic.oup.com
Context The dopamine agonist cabergoline (CAB) has been used widely in the treatment of
prolactinomas and other types of pituitary adenomas, but its clinical use is hampered by …

RNAi-mediated knockdown of INHBB increases apoptosis and inhibits steroidogenesis in mouse granulosa cells

M M'BAYE, G Hua, HA Khan, L Yang - Journal of Reproduction and …, 2015 - jstage.jst.go.jp
Inhibins are members of the TGFβ superfamily and act as suppressors of follicle stimulating
hormone (FSH) secretion from pituitary glands via a negative feedback mechanism to …

Luzindole and 4P-PDOT block the effect of melatonin on bovine granulosa cell apoptosis and cell cycle depending on its concentration

S Wang, W Liu, A Wen, B Yang, X Pang - PeerJ, 2021 - peerj.com
Granulosa cells play an essential physiological role in mediating the follicle development
and survival or apoptosis of granulosa cells dictate the follicle development or atresia. The …

Knockdown of CEBPβ by RNAi in porcine granulosa cells resulted in S phase cell cycle arrest and decreased progesterone and estradiol synthesis

YH Zhen, L Wang, H Riaz, JB Wu, YF Yuan… - The Journal of Steroid …, 2014 - Elsevier
Cultured ovarian granulosa cells (GCs) are essential models to study molecular
mechanisms of gene regulation during folliculogenesis. CCAAT enhancer binding proteins β …

Decreased expression of APAF-1 and increased expression of cathepsin B in invasive pituitary adenoma

C Tanase, R Albulescu, E Codrici, B Calenic… - OncoTargets and …, 2014 - Taylor & Francis
Purpose Apoptotic protease-activating factor-1 (APAF-1) and cathepsin B are important
functional proteins in apoptosis; the former is involved in the intrinsic (mitochondrial) …

Whole transcriptome analysis to identify non-coding RNA regulators and hub genes in sperm of non-obstructive azoospermia by microarray, single-cell RNA …

DH Karoii, H Azizi, T Skutella - BMC genomics, 2024 - Springer
Background The issue of male fertility is becoming increasingly common due to genetic
differences inherited over generations. Gene expression and evaluation of non-coding RNA …

Inhibin A regulates follicular development via hormone secretion and granulosa cell behaviors in laying hens

Z Cui, L Liu, Q Zhu, Y Wang, H Yin, D Li, Y Tian… - Cell and tissue …, 2020 - Springer
Inhibin A regulates follicular development, and its expression level is related to physiological
activities, such as the recruitment, selection, and predominance during follicular …