Surviving the heat: the role of macromolecular assemblies in promoting cellular shutdown
CD Altamirano, S Alberti - Trends in Biochemical Sciences, 2024 - cell.com
During heat shock (HS), cells orchestrate a gene expression program that promotes the
synthesis of HS proteins (HSPs) while simultaneously repressing the synthesis of other …
synthesis of HS proteins (HSPs) while simultaneously repressing the synthesis of other …
Preserve or destroy: Orphan protein proteostasis and the heat shock response
A Ali, S Paracha, D Pincus - Journal of Cell Biology, 2024 - rupress.org
Most eukaryotic genes encode polypeptides that are either obligate members of hetero-
stoichiometric complexes or clients of organelle-targeting pathways. Proteins in these …
stoichiometric complexes or clients of organelle-targeting pathways. Proteins in these …
Molecular basis for thiocarboxylation and release of Urm1 by its E1-activating enzyme Uba4
M Sokołowski, D Kwasna… - Nucleic Acids …, 2024 - academic.oup.com
Abstract Ubiquitin-related modifier 1 (Urm1) is a highly conserved member of the ubiquitin-
like (UBL) family of proteins. Urm1 is a key component of the eukaryotic transfer RNA (tRNA) …
like (UBL) family of proteins. Urm1 is a key component of the eukaryotic transfer RNA (tRNA) …
Ubiquitin and Ubiquitin‐Like Modifications in Organelle Stress Signaling: Ub, Ub, Ub, Ub, Stayin'Alive, Stayin'Alive
Due to various intracellular and external cues, cellular organelles are frequently stressed in
both physiological and pathological conditions. Sensing these stresses initiates various …
both physiological and pathological conditions. Sensing these stresses initiates various …