Muscles and bones are intricately connected tissues displaying marked co-variation during
development, growth, aging, and in many diseases. While the diagnosis and treatment of …

Exercise, in the form of endurance or resistance training, leads to specific molecular and
cellular adaptions not only in skeletal muscles, but also in many other organs such as the …

Sarcopenia (Sp) is the loss of skeletal muscle mass associated with aging which causes an
involution of muscle function and strength. Satellite cells (Sc) are myogenic stem cells, which …

Muscle fiber denervation is a major contributor to the decline in physical function observed
with aging. Denervation can occur through breakdown of the neuromuscular junctions (NMJ) …

Skeletal muscle health and function are important determinants of systemic metabolic
homeostasis and organism-wide responses, including disease outcome. While it is well …

Sarcopenia is a progressive loss of muscle mass and strength with a risk of adverse
outcomes such as disability, poor quality of life, and death. Increasing evidence indicates …

Extracellular vesicles (EVs) are nanoparticles released from various cell types that have
emerged as powerful new therapeutic option for a variety of diseases. EVs are involved in …

Background Previous studies have shown that osteoarthritis (OA) and sarcopenia (SP) are
closely related to each other, but the causal relationships between them have not been …

Metrnl is a secreted protein able to activate different intracellular signaling pathways in
adipocytes, macrophages, myocytes and cardiomyocytes with physiological effects of the …

Voluntary striated muscles are characterized by a highly complex and dynamic proteome
that efficiently adapts to changed physiological demands or alters considerably during …